Title:
CYTOCIDAL AGENT
Document Type and Number:
WIPO Patent Application WO/2019/039540
Kind Code:
A1
Abstract:
The present invention pertains to: a cytocidal agent which comprises a peptide comprising the amino acid sequence represented by SEQ ID NO: 1 and a site capable of selectively binding to a target molecule; and the cytocidal agent wherein the peptide comprising the amino acid sequence represented by SEQ ID NO: 1 is a peptide consisting exclusively of L-amino acids, a peptide wherein, in the amino acid sequence represented by SEQ ID NO: 1, the 1st to 14th amino acids are D-amino acids and the 15th to 19th amino acids are L-amino acids, a peptide wherein, in the amino acid sequence represented by SEQ ID NO: 1, the 1st to 14th amino acids are L-amino acids and the 15th to 19th amino acids are D-amino acids, or a peptide consisting exclusively of D-amino acids.
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Inventors:
SUGIHARA KAZUHIRO (JP)
KANAYAMA NAOHIRO (JP)
ONODERA YUICHIRO (JP)
SHIBATA TOSHIAKI (JP)
FUKUDA MICHIKO (JP)
NONAKA MOTOHIRO (JP)
KANAYAMA NAOHIRO (JP)
ONODERA YUICHIRO (JP)
SHIBATA TOSHIAKI (JP)
FUKUDA MICHIKO (JP)
NONAKA MOTOHIRO (JP)
Application Number:
PCT/JP2018/031136
Publication Date:
February 28, 2019
Filing Date:
August 23, 2018
Export Citation:
Assignee:
FUJITA ACAD (JP)
International Classes:
A61K38/10; A01K67/027; A61K47/66; A61P15/00; A61P35/00; A61P43/00; C07K7/08; C07K19/00
Domestic Patent References:
| WO2015041019A1 | 2015-03-26 |
Foreign References:
| US20160145308A1 | 2016-05-26 | |||
| JP2013523824A | 2013-06-17 | |||
| JP2017161556A | 2017-09-14 | |||
| US20160145308A1 | 2016-05-26 |
Other References:
SUGIHARA, KAZUHIRO ET AL: "Search of peptide therapeutic drugs for endometriosis", PROGRAMS AND ABSTRACTS OF THE 32ND ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 2016, pages 170, XP009519434
SHIBATA, TOSHIAKI ET AL: "P3-14-1 Anti-tumor drugs using peptide that mimics sugar chains", ACTA OBSTETRICA ET GYNAECOLOGICA JAPONICA, vol. 68, no. 2, 2016, pages 858, XP009519433, ISSN: 0300-9165
SUGIHARA, K. ET AL.: "Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis", NATURE COMMUNICATIONS, vol. 5, no. 4478, 2014, pages 1 - 9, XP055255332, ISSN: 2041-1723, DOI: 10.1038/ncomms5478
SUGIHARA ET AL., NATURE COMMUNICATIONS, vol. 5, 2014
See also references of EP 3738601A4
SHIBATA, TOSHIAKI ET AL: "P3-14-1 Anti-tumor drugs using peptide that mimics sugar chains", ACTA OBSTETRICA ET GYNAECOLOGICA JAPONICA, vol. 68, no. 2, 2016, pages 858, XP009519433, ISSN: 0300-9165
SUGIHARA, K. ET AL.: "Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis", NATURE COMMUNICATIONS, vol. 5, no. 4478, 2014, pages 1 - 9, XP055255332, ISSN: 2041-1723, DOI: 10.1038/ncomms5478
SUGIHARA ET AL., NATURE COMMUNICATIONS, vol. 5, 2014
See also references of EP 3738601A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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