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Title:
CYTOSINE-TYPE CROSSLINKED NUCLEOSIDE AMIDITE CRYSTALS AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2022/124410
Kind Code:
A1
Abstract:
Provided are cytosine-type crosslinked nucleoside amidite crystals represented by a structural formula. In the formula, R2 and R2 are substitution groups and R3 is a protector group.

Inventors:
KOHGO SATORU (JP)
Application Number:
PCT/JP2021/045679
Publication Date:
June 16, 2022
Filing Date:
December 10, 2021
Export Citation:
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Assignee:
YAMASA CORP (JP)
International Classes:
C07H19/067
Domestic Patent References:
WO2019224172A12019-11-28
WO2020099533A12020-05-22
Foreign References:
JP2004536125A2004-12-02
JP2002521310A2002-07-16
Other References:
KAORU : "Recrystallization method and precipitation method", EXPERIMENTAL CHEMISTRY COURSE (CONTINUED) 2 SEPARATION AND PURIFICATION, 25 January 1967 (1967-01-25), pages 159-178, 186 - 187, XP009509740
KOSHKIN, A.A. SINGH, S.K. NIELSEN, P. RAJWANSHI, V.K. KUMAR, R. MELDGAARD, M. OLSEN, C.E. WENGEL, J.: "LNA (Locked Nucleic Acids): Synthesis of the Adenine, Cytosine, Guanine, 5-Methylcytosine, Thymine and Uracil Bicyclonucleoside Monomers, Oligomerisation, and Unprecedented Nucleic Acid Recognition", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 54, no. 14, 2 April 1998 (1998-04-02), AMSTERDAM, NL , pages 3607 - 3630, XP004110505, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(98)00094-5
SORENSEN M D,ET AL: "alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): Synthesis and properties", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 124, no. 10, 13 March 2002 (2002-03-13), pages 2164 - 2176, XP002281373, ISSN: 0002-7863, DOI: 10.1021/ja0168763
NIELSEN POUL, ET AL.: "α-LNA (locked nucleic acid with α-D-configuration): synthesis and selective parallel recognition of RNA", CHEMISTRY-A EUROPEAN JOURNAL, vol. 8, no. 3, 2 February 2002 (2002-02-02), pages 712 - 722, XP055940870, DOI: 10.1002/1521-3765(20020201)8:3<712::AID-CHEM712>3.0.CO;2-0
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL (JP)
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