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Patent Searching and Data


Title:
DAPAGLIFLOZIN CRYSTAL FORM, PREPARATION THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/151672
Kind Code:
A1
Abstract:
Provided are a new crystal form of dapagliflozin and a preparation method therefor, a pharmaceutical composition comprising the crystal form, and a use of the crystal form in preparation of a sodium-glucose cotransporter inhibitor and a pharmaceutical preparation for treating diabetes. Compared with the prior art, the provided dapagliflozin crystal form CSI has one or more improved properties, and is of great value to the optimization and development of this drug in the future.

Inventors:
CHEN MINHUA (CN)
CHANG XINGJUAN (CN)
LIU YUAN (CN)
ZHANG HAOWEI (CN)
Application Number:
PCT/CN2020/073287
Publication Date:
July 30, 2020
Filing Date:
January 20, 2020
Export Citation:
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Assignee:
CRYSTAL PHARMACEUTICAL SUZHOU CO LTD (CN)
International Classes:
C07D309/10; A61K31/351; A61P3/10
Domestic Patent References:
WO2016155578A12016-10-06
Foreign References:
CN105237502A2016-01-13
CN107641139A2018-01-30
CN104829573A2015-08-12
Other References:
JUN YU, CAO YING, YU HAIZHOU, WANG JINJIA: "A Concise and Efficient Synthesis of Dapagliflozin", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 23, 27 June 2019 (2019-06-27), pages 1458 - 1461, XP055723751, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.9b00141
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