Title:
DECLADINOSYL-MACROLIDES WITH ANTI-INFLAMMATORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO2006077501
Kind Code:
A3
Abstract:
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-a, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
Inventors:
CULIC OGNJEN (HR)
BOSNAR MARTINA (HR)
ALIHODZIC SULEJMAN (HR)
LAZAREVSKI GORJANA (HR)
ISTUK MARUSIC ZORICA (HR)
HUTINEC ANTUN (HR)
VELA VANJA (HR)
KRAGOL GORAN (HR)
BOSNAR MARTINA (HR)
ALIHODZIC SULEJMAN (HR)
LAZAREVSKI GORJANA (HR)
ISTUK MARUSIC ZORICA (HR)
HUTINEC ANTUN (HR)
VELA VANJA (HR)
KRAGOL GORAN (HR)
Application Number:
PCT/IB2006/001097
Publication Date:
November 09, 2006
Filing Date:
January 13, 2006
Export Citation:
Assignee:
GLAXOSMITHKLINE ZAGREB (HR)
CULIC OGNJEN (HR)
BOSNAR MARTINA (HR)
ALIHODZIC SULEJMAN (HR)
LAZAREVSKI GORJANA (HR)
ISTUK MARUSIC ZORICA (HR)
HUTINEC ANTUN (HR)
VELA VANJA (HR)
KRAGOL GORAN (HR)
CULIC OGNJEN (HR)
BOSNAR MARTINA (HR)
ALIHODZIC SULEJMAN (HR)
LAZAREVSKI GORJANA (HR)
ISTUK MARUSIC ZORICA (HR)
HUTINEC ANTUN (HR)
VELA VANJA (HR)
KRAGOL GORAN (HR)
International Classes:
C07H17/08; A61K31/7048
Domestic Patent References:
WO2004039821A1 | 2004-05-13 | |||
WO2002012260A1 | 2002-02-14 |
Foreign References:
EP0619320A1 | 1994-10-12 | |||
EP0775489A1 | 1997-05-28 | |||
EP0771564A1 | 1997-05-07 | |||
EP0487411A1 | 1992-05-27 |
Other References:
TANIKAWA T ET AL: "SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF ACYLIDES (3-O-ACYL-ERYTHROMYCIN DERIVATIVES): A NOVEL CLASS OF MACROLIDE ANTIBIOTICS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, no. 24, 22 November 2001 (2001-11-22), pages 4027 - 4030, XP001179489, ISSN: 0022-2623
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