Title:
DERIVATIVE OF 2,5-DIKETOPIPERAZINE COMPOUND, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/144002
Kind Code:
A1
Abstract:
Disclosed are a derivative of a 2,5-diketopiperazine compound, and a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed are a compound as represented by formula (I), a stereoisomer thereof, a tautomer thereof or a pharmaceutically acceptable salt thereof, or a solvate of any one of the aforementioned. The compound is new in terms of structure, and has good anti-tumor activity and water solubility.
Inventors:
LI WENBAO WILLIAM (CN)
DING ZHONGPENG (CN)
LI FEIFEI (CN)
XIE LIANGHUI (CN)
XU YUN (CN)
WANG XINWEN (CN)
DING ZHONGPENG (CN)
LI FEIFEI (CN)
XIE LIANGHUI (CN)
XU YUN (CN)
WANG XINWEN (CN)
Application Number:
PCT/CN2021/143913
Publication Date:
July 07, 2022
Filing Date:
December 31, 2021
Export Citation:
Assignee:
DALIAN WZ PROBIOTICS AD HEALTH CO LTD (CN)
International Classes:
C07D403/14; A61K31/496; A61K31/5377; A61P35/00; C07D401/06; C07D403/06; C07D405/14; C07D409/14; C07D417/14
Domestic Patent References:
| WO2012035436A1 | 2012-03-22 |
Foreign References:
| CN110240592A | 2019-09-17 | |||
| CN107286137A | 2017-10-24 | |||
| CN106279039A | 2017-01-04 | |||
| CN110835335A | 2020-02-25 | |||
| CN202011624889A | 2020-12-31 |
Other References:
DING, ZHONGPENG ET AL. .: "Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 28, no. 10, 13 March 2020 (2020-03-13), XP086135480, DOI: 10.1016/j.bmc.2020.115435
CAS, no. 714272-27-2
CAS, no. 714272-27-2
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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