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Title:
DEUTERATED COMPOUND AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/141192
Kind Code:
A1
Abstract:
The present invention relates to a compound as represented by structural formula (I) and a non-toxic, pharmaceutically acceptable salt thereof. In formula (I), R1 is H, CH3 or deuterated methyl(CD3); R2 is CH3 or CH2CH3; each of R3, R4 and R5 is independently H or deuterium (D); and when R1 is H or CH3, at least one of R3, R4 and R5 has to be D.

Inventors:
ZHONG BOHUA (CN)
WANG JIANMING (CN)
YANG JIAJUN (CN)
Application Number:
PCT/CN2018/000051
Publication Date:
August 09, 2018
Filing Date:
January 26, 2018
Export Citation:
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Assignee:
TEIZHOU HUAYUAN MEDICINAL TECH CO LTD (CN)
International Classes:
C07D489/12
Domestic Patent References:
WO2006091885A22006-08-31
WO2014087226A12014-06-12
Foreign References:
US20090082383A12009-03-26
Other References:
A. POLETTINI ET AL.: "Simultaneous Determination of Buprenorphine, Norbuprenorphine, and Buprenorphine-Glucuronide in Plasma by Liquid Chromatography-Tandem Mass Spectrometry", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES AND APPLICATIONS, vol. 754, no. 2, 25 April 2001 (2001-04-25), pages 447 - 459, XP004232829, ISSN: 0378-4347
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