Title:
DEUTERATED PENTAZOCINE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/180081
Kind Code:
A1
Abstract:
Provided is a compound having the structure represented by formula (I), or a stereoisomer, N-oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug thereof. Further provided are a pharmaceutical composition comprising the compound having the structure represented by formula (I), a preparation method therefor, and an intermediate and analgesic application thereof.
Inventors:
XU KUI (CN)
ZHAO HONG (CN)
LIU YIFAN (CN)
ZHAN SHUSHENG (CN)
ZHAO HONG (CN)
LIU YIFAN (CN)
ZHAN SHUSHENG (CN)
Application Number:
PCT/CN2021/079781
Publication Date:
September 16, 2021
Filing Date:
March 09, 2021
Export Citation:
Assignee:
ANHUI HEALSTAR PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D221/26; A61K31/439; A61P29/00
Foreign References:
CN111217749A | 2020-06-02 | |||
US4105659A | 1978-08-08 | |||
US3644373A | 1972-02-22 | |||
CN107827819A | 2018-03-23 | |||
GB1330464A | 1973-09-19 |
Other References:
CHOI SEOUNG-RYOUNG, BREUGST MARTIN, HOUK KENDALL N., POULTER C. DALE: "δ-Deuterium Isotope Effects as Probes for Transition-State Structures of Isoprenoid Substrates", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 79, no. 8, 18 April 2014 (2014-04-18), pages 3572 - 3580, XP055846738, ISSN: 0022-3263, DOI: 10.1021/jo500394u
MILLER DAVID J., GAO JIALI, TRUHLAR DONALD G., YOUNG NEIL J., GONZALEZ VERONICA, ALLEMANN RUDOLF K.: "Stereochemistry of eudesmane cation formation during catalysis by aristolochene synthase from Penicillium roqueforti", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 6, no. 13, 7 July 2008 (2008-07-07), pages 2346 - 2354, XP055846742, ISSN: 1477-0520, DOI: 10.1039/b804198a
MILLER DAVID J., GAO JIALI, TRUHLAR DONALD G., YOUNG NEIL J., GONZALEZ VERONICA, ALLEMANN RUDOLF K.: "Stereochemistry of eudesmane cation formation during catalysis by aristolochene synthase from Penicillium roqueforti", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 6, no. 13, 7 July 2008 (2008-07-07), pages 2346 - 2354, XP055846742, ISSN: 1477-0520, DOI: 10.1039/b804198a
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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