Title:
DEVICE FOR CONTINUOUSLY PREPARING 2,6-DIHYDROXYBENZALDEHYDE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/046815
Kind Code:
A1
Abstract:
The present invention provides a device for continuously preparing 2,6-dihydroxybenzaldehyde and an application thereof. The device comprises a first continuous reaction unit for hydroxyl protection reaction, a second continuous reaction unit for lithiation hydroformylation reaction, and a third continuous reaction unit for protective group removal reaction which are sequentially connected in series, wherein the third continuous reaction unit comprises a first columnar continuous reactor which is connected to the second continuous reaction unit and used for performing liquid separation while performing protective group removal treatment on a lithiation hydroformylation product to obtain an organic phase containing the 2, 6-dihydroxybenzaldehyde and a water phase. When the device is applied to the preparation of the 2, 6-dihydroxybenzaldehyde, the reaction time is shortened, and intermediate purification treatment is not needed, so that compared with a batch process, the equipment cost and the post-treatment cost can be greatly saved, the production efficiency is greatly improved, and the industrialized enlarged production of the 2, 6-dihydroxybenzaldehyde is more facilitated.
Inventors:
HONG HAO (US)
LU JIANGPING (CN)
FENG XICHUN (CN)
ZHANG XIN (CN)
YAN BO (CN)
LU JIANGPING (CN)
FENG XICHUN (CN)
ZHANG XIN (CN)
YAN BO (CN)
Application Number:
PCT/CN2019/105754
Publication Date:
March 18, 2021
Filing Date:
September 12, 2019
Export Citation:
Assignee:
ASYMCHEM LABORATORIES FUXIN CO LTD (CN)
International Classes:
B01J19/00; B01J4/00; B01J19/18; B01J19/24; C07C41/54; C07C43/303; C07C45/64; C07C47/565
Foreign References:
| CN109152770A | 2019-01-04 | |||
| CN108892616A | 2018-11-27 | |||
| US20080194816A1 | 2008-08-14 |
Other References:
SETO MASAKI, MASADA SHINICHI, USUTANI HIROTSUGU, CORK DAVID G., FUKUDA KOICHIRO, KAWAMOTO TETSUJI: "Application of Continuous Flow-Flash Chemistry to Scale-up Synthesis of 5-Cyano-2-formylbenzoic Acid", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 23, no. 7, 19 July 2019 (2019-07-19), US, pages 1420 - 1428, XP055790080, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.9b00180
Attorney, Agent or Firm:
KANGXIN PARTNERS, P.C. (CN)
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