Title:
DEVICES AND METHODS FOR RADIOPHARMACEUTICAL SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2021/002913
Kind Code:
A3
Abstract:
A device for synthesizing a radioisotope-labelled target tracer includes a microfluidic chip having an SCX module configured to concentrate and capture a radioisotope from a radioisotope solution and release the captured radioisotope therefrom, an SAX module configured to purify the released radioisotope from the SCX module, and an passive in-plane mixing/reaction module configured to mix the purified radioisotope with a target precursor and perform labelling reaction to synthesize the radioisotope-labelled target tracer therein. The device also includes a heating means positioned in relation to the microfluidic chip for heating the microfluidic chip during the labelling reaction; and a first valve fluidically coupled with the SCX and SAX modules and a second valve fluidically coupled with the SAX module and the in-plane mixing/reaction module for operably controlling transit of various substances or mixtures among the SCX module, the SAX modules and the in-plane mixing/reaction module.
Inventors:
MANNING H CHARLES (US)
NICKELS MICHAEL L (US)
ZHANG XIN (US)
BELLAN LEON M (US)
NICKELS MICHAEL L (US)
ZHANG XIN (US)
BELLAN LEON M (US)
Application Number:
PCT/US2020/027019
Publication Date:
March 18, 2021
Filing Date:
April 07, 2020
Export Citation:
Assignee:
UNIV VANDERBILT (US)
International Classes:
A61K51/04; B01J19/00; B01L3/00
Foreign References:
| US20120283490A1 | 2012-11-08 |
Other References:
ZHANG, XIN, FEI LIU , KARLA-ANNE KNAPP , MICHAEL L NICKELS: "A simple microfluidic platform for rapid and efficient production of the radiotracer [18F] fallypride", LAB ON A CHIP, vol. 18, no. 9, 1 April 2019 (2019-04-01), pages 1369 - 1377, XP055790561
ALVES F., ALVES V. H., NEVES A. C. B., DO CARMO S. J. C., NACTERGAL B., HELLAS V., KRAL E., GONÇALVES-GAMEIRO C., ABRUNHOSA A. J.: "Cyclotron production of Ga-68 for human use from liquid targets: From theory to practice", AIP CONFERENCE PROCEEDINGS, AMERICAN INSTITUTE OF PHYSICS, NEW YORK, US, vol. 1845, 1 January 2017 (2017-01-01), NEW YORK, US, pages 020001, XP055790562, ISSN: 0094-243X, DOI: 10.1063/1.4983532
IANOVSKA, MARGARYTA, "Microfluidic tools for multidimensional liquid chromatography", Doctoral dissertation, University of Groningen, 2018, pages 39-84 See page 46, lines 2-4, lines 9-11; page 64, lines 17-21; and figure 6E. Y 12-15,27
WALDBAUR, ANSGAR: "Microfluidics on liquid handling stations (μF-on-LHS): an industry compatible chip interface between microfluidics and automated liquid handling stations", LAB ON A CHIP, vol. 13, 1 May 2013 (2013-05-01), pages 2337 - 2343, XP055790566
ALVES F., ALVES V. H., NEVES A. C. B., DO CARMO S. J. C., NACTERGAL B., HELLAS V., KRAL E., GONÇALVES-GAMEIRO C., ABRUNHOSA A. J.: "Cyclotron production of Ga-68 for human use from liquid targets: From theory to practice", AIP CONFERENCE PROCEEDINGS, AMERICAN INSTITUTE OF PHYSICS, NEW YORK, US, vol. 1845, 1 January 2017 (2017-01-01), NEW YORK, US, pages 020001, XP055790562, ISSN: 0094-243X, DOI: 10.1063/1.4983532
IANOVSKA, MARGARYTA, "Microfluidic tools for multidimensional liquid chromatography", Doctoral dissertation, University of Groningen, 2018, pages 39-84 See page 46, lines 2-4, lines 9-11; page 64, lines 17-21; and figure 6E. Y 12-15,27
WALDBAUR, ANSGAR: "Microfluidics on liquid handling stations (μF-on-LHS): an industry compatible chip interface between microfluidics and automated liquid handling stations", LAB ON A CHIP, vol. 13, 1 May 2013 (2013-05-01), pages 2337 - 2343, XP055790566
Attorney, Agent or Firm:
XIA, Tim Tingkang (US)
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