Title:
DEXAMETHASONE-LOADED MACROPHAGE-DERIVED MICROVESICLE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/210638
Kind Code:
A1
Abstract:
A dexamethasone-loaded macrophage-derived microvesicle, a preparation method therefor, and an application thereof. The dexamethasone-loaded macrophage-derived microvesicle is formed by loading dexamethasone in a microvesicle derived from murine macrophage cell line RAW 264.7. The prepared dexamethasone-loaded macrophage-derived microvesicle can be used for preparing a medication or preparation for treating kidney disease, and can also be applied in preparation of an anti-inflammatory or immunosuppressive drug or preparation.
Inventors:
LIU BICHENG (CN)
TANG TAOTAO (CN)
LV LINLI (CN)
TANG TAOTAO (CN)
LV LINLI (CN)
Application Number:
PCT/CN2018/106859
Publication Date:
November 07, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
UNIV SOUTHEAST (CN)
International Classes:
A61K9/50; A61K9/127; A61K31/573; A61K47/46; A61P13/12; A61P29/00; A61P37/06
Foreign References:
| CN102596177A | 2012-07-18 | |||
| CN107427466A | 2017-12-01 |
Other References:
INTRATHECAL INJECTION OF GLUCOCORRICOID RECEPTOR AGONIST DEXAMETHASONE REDUCES THE PROINFLAMMATORY FACTORS OF IL -6 AND TNF-ALPHA AND RELIEVES EARLY NEUROPATHIC PAIN INDUCED BY NERVE INJURY IN RATS, vol. 33, no. 2, 31 December 2017 (2017-12-31)
FANG, YAO ET AL.: "Progress in Modern Biomedicine", RAW264.7 (CULTURE SKILL AND EXPERIENCE OF RA W264.7, vol. 12, no. 22, 31 August 2012 (2012-08-31)
FANG, YAO ET AL.: "Progress in Modern Biomedicine", RAW264.7 (CULTURE SKILL AND EXPERIENCE OF RA W264.7, vol. 12, no. 22, 31 August 2012 (2012-08-31)
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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