Title:
DIACYLETHYLENEDIAMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/122968
Kind Code:
A1
Abstract:
Disclosed is a compound useful as an anti-obesity agent.
Studies have been made on compounds which have a DGAT1 inhibitory activity and are therefore promising active ingredients for pharmaceutical compositions for treating obesity, type-II diabetes, fatty liver and diseases associated with the aforementioned diseases, and it is confirmed that a specific diacylethylenediamine compound has an excellent DGAT1 inhibitory activity. The diacylethylenediamine compound has a DGAT1 inhibitory activity and can be used as a prophylactic and/or therapeutic agent for obesity, type-II diabetes, fatty liver and diseases associated with the aforementioned diseases.
Inventors:
KAWANO TOMOAKI (JP)
YONETOKU YASUHIRO (JP)
HANAZAWA TAKESHI (JP)
NIGAWARA TAKAHIRO (JP)
FUKUDOME HIROKI (JP)
MORITANI HIROSHI (JP)
YONETOKU YASUHIRO (JP)
HANAZAWA TAKESHI (JP)
NIGAWARA TAKAHIRO (JP)
FUKUDOME HIROKI (JP)
MORITANI HIROSHI (JP)
Application Number:
PCT/JP2010/056901
Publication Date:
October 28, 2010
Filing Date:
April 19, 2010
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KAWANO TOMOAKI (JP)
YONETOKU YASUHIRO (JP)
HANAZAWA TAKESHI (JP)
NIGAWARA TAKAHIRO (JP)
FUKUDOME HIROKI (JP)
MORITANI HIROSHI (JP)
KAWANO TOMOAKI (JP)
YONETOKU YASUHIRO (JP)
HANAZAWA TAKESHI (JP)
NIGAWARA TAKAHIRO (JP)
FUKUDOME HIROKI (JP)
MORITANI HIROSHI (JP)
International Classes:
C07C235/46; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/402; A61K31/4035; A61K31/404; A61K31/41; A61K31/415; A61K31/421; A61K31/4245; A61K31/425; A61K31/427; A61K31/428; A61K31/4365; A61K31/439; A61K31/44; A61K31/445; A61K31/451; A61K31/4535; A61K31/4545; A61K31/455; A61K31/47; A61K31/495; A61K31/4985; A61K31/505; A61K31/5375; A61P1/16; A61P3/04; A61P3/10; A61P43/00; C07C235/84; C07C237/34; C07C255/46; C07C275/26; C07C275/28; C07C307/06; C07C311/51; C07C317/44; C07C323/62; C07D207/06; C07D209/08; C07D209/42; C07D209/44; C07D211/16; C07D211/34; C07D211/44; C07D211/60; C07D213/81; C07D213/82; C07D215/48; C07D217/26; C07D231/22; C07D239/42; C07D241/04; C07D257/04; C07D263/32; C07D263/34; C07D263/48; C07D271/06; C07D271/10; C07D275/02; C07D277/20; C07D277/56; C07D277/68; C07D295/14; C07D295/18; C07D295/20; C07D307/79; C07D309/06; C07D317/46; C07D319/18; C07D333/38; C07D333/54; C07D333/68; C07D333/70; C07D451/02; C07D495/04
Domestic Patent References:
| WO2008011131A2 | 2008-01-24 | |||
| WO2006082952A1 | 2006-08-10 | |||
| WO2008011130A2 | 2008-01-24 | |||
| WO2008011131A2 | 2008-01-24 | |||
| WO2007141517A1 | 2007-12-13 | |||
| WO2007138304A1 | 2007-12-06 | |||
| WO2007138311A1 | 2007-12-06 | |||
| WO2006064189A1 | 2006-06-22 | |||
| WO2009076618A2 | 2009-06-18 | |||
| WO2007115935A1 | 2007-10-18 |
Foreign References:
| JPH0377881A | 1991-04-03 |
Other References:
See also references of EP 2423182A4
PROC. NAT. ACAD. SCI., vol. 95, 1998, pages 13018 - 13023
J. BIOL. CHEM., vol. 276, 2001, pages 38870 - 38876
NATURE GENETICS, vol. 25, 2000, pages 87 - 90
J. CLIN. INVEST., vol. 109, 2002, pages 1049 - 1055
ARTERIOSCLER. THROMB. VASE. BIOL., vol. 25, 2005, pages 482 - 486
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, vol. 25, no. 2, 2009, pages 178 - 182
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
"Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 24, 1993, pages 3968 - 3970
PROC. NAT. ACAD. SCI., vol. 95, 1998, pages 13018 - 13023
J. BIOL. CHEM., vol. 276, 2001, pages 38870 - 38876
NATURE GENETICS, vol. 25, 2000, pages 87 - 90
J. CLIN. INVEST., vol. 109, 2002, pages 1049 - 1055
ARTERIOSCLER. THROMB. VASE. BIOL., vol. 25, 2005, pages 482 - 486
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, vol. 25, no. 2, 2009, pages 178 - 182
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
"Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 24, 1993, pages 3968 - 3970
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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