Title:
DIAGNOSIS METHOD FOR FATTY LIVER DISEASE, DIAGNOSIS APPARATUS, DIAGNOSIS PROGRAM, DIAGNOSTIC AGENT, AND METHOD FOR SCREENING FOR THERAPEUTIC AGENT FOR FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2008/056480
Kind Code:
A1
Abstract:
Disclosed is a diagnosis method which enables the diagnosis of steatohepatitis
in a simpler manner than a conventional liver biopsy. The diagnosis method comprises
the steps of: measuring a choline level in a blood-derived sample collected from
a subject; and determining the occurrence of a fatty liver disease, the severity
of the disease or the efficacy of a therapy on the disease based on the choline level.
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Inventors:
NAKAJIMA ATSUSHI (JP)
YONEDA MASATO (JP)
FUJITA KOJI (JP)
NAKAE DAI (JP)
TAKAMURA TAKEJI (JP)
TAKAHASHI MASAKAZU (JP)
HATANAKA YUTAKA (JP)
YONEDA MASATO (JP)
FUJITA KOJI (JP)
NAKAE DAI (JP)
TAKAMURA TAKEJI (JP)
TAKAHASHI MASAKAZU (JP)
HATANAKA YUTAKA (JP)
Application Number:
PCT/JP2007/067029
Publication Date:
May 15, 2008
Filing Date:
August 31, 2007
Export Citation:
Assignee:
UNIV YOKOHAMA CITY (JP)
NAKAJIMA ATSUSHI (JP)
YONEDA MASATO (JP)
FUJITA KOJI (JP)
NAKAE DAI (JP)
TAKAMURA TAKEJI (JP)
TAKAHASHI MASAKAZU (JP)
HATANAKA YUTAKA (JP)
NAKAJIMA ATSUSHI (JP)
YONEDA MASATO (JP)
FUJITA KOJI (JP)
NAKAE DAI (JP)
TAKAMURA TAKEJI (JP)
TAKAHASHI MASAKAZU (JP)
HATANAKA YUTAKA (JP)
International Classes:
G01N33/50; C12Q1/26; G01N33/15
Foreign References:
| JPS59140899A | 1984-08-13 | |||
| JP2006299978A | 2006-11-02 | |||
| JP3899041B2 | 2007-03-28 |
Other References:
NEHRA V. ET AL.: "Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis", DIGESTIVE DISEASES AND SCIENCES, vol. 46, no. 11, 2001, pages 2347 - 2352, XP003022529
DUMAS M.-E. ET AL.: "Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice", PROC. NATL. ACAD. SCI. USA, vol. 103, no. 33, 15 August 2006 (2006-08-15), pages 12511 - 12516, XP003022530
See also references of EP 2133692A4
JOHN B. DIXON ET AL., GASTROENTEROLOGY, 2001, pages 121,91 - 100
GASTROENTEROLOGY, vol. 123, 2002, pages 1705 - 1725
NEHRA ET AL., DIGESTIVE DISEASES AND SCIENCES, vol. 46, 2001, pages 2347 - 2352
HISE ET AL., ANALYTICAL BIOCHEMISTRY, vol. 135, 1983, pages 78 - 82
DUMAS M.-E. ET AL.: "Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice", PROC. NATL. ACAD. SCI. USA, vol. 103, no. 33, 15 August 2006 (2006-08-15), pages 12511 - 12516, XP003022530
See also references of EP 2133692A4
JOHN B. DIXON ET AL., GASTROENTEROLOGY, 2001, pages 121,91 - 100
GASTROENTEROLOGY, vol. 123, 2002, pages 1705 - 1725
NEHRA ET AL., DIGESTIVE DISEASES AND SCIENCES, vol. 46, 2001, pages 2347 - 2352
HISE ET AL., ANALYTICAL BIOCHEMISTRY, vol. 135, 1983, pages 78 - 82
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
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