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Title:
DIAGNOSIS AND PROGNOSIS OF BREAST CANCER PATIENTS
Document Type and Number:
WIPO Patent Application WO2002103320
Kind Code:
A3
Abstract:
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

Inventors:
DAI HONGYUE
HE YUDONG
LINSLEY PETER S
MAO MAO
ROBERTS CHRISTOPHER J
VAN T VEER LAURA JOHANNA
VAN DE VIJVER MARC J
BERNARDS RENE
HART A A M
Application Number:
PCT/US2002/018947
Publication Date:
July 31, 2003
Filing Date:
June 14, 2002
Export Citation:
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Assignee:
ROSETTA INPHARMATICS INC (US)
International Classes:
G01N33/53; C12M1/00; C12N15/09; C12Q1/02; G01N33/566; G01N33/574; G01N37/00; G06F19/20; G06F19/24; (IPC1-7): G01N33/48
Foreign References:
US6342491B12002-01-29
US6358682B12002-03-19
US6107034A2000-08-22
US6342483B12002-01-29
US6455300B12002-09-24
Other References:
SORLIE ET AL: "Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications", PROC NAT ACAD OF SCI USA, vol. 98, no. 19, 11 September 2001 (2001-09-11), pages 10869 - 10874, XP002215483
LAIRD ET AL: "Deficiency of Connexin43 gap junctions is an independent marker for breast tumors", CANCER RESEARCH, vol. 59, 15 August 1999 (1999-08-15), pages 4104 - 4110, XP002963203
See also references of EP 1410011A4
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