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Title:
DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS
Document Type and Number:
WIPO Patent Application WO2004022529
Kind Code:
A3
Abstract:
The present invention relates to novel diarylurea derivatives represented by general formula (I) useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.

Inventors:
DAHL BJARNE H (DK)
CHRISTOPHERSEN PALLE (DK)
ENGSIG MICHAEL THYRRING (DK)
KARSDAL MORTEN ASSER (DK)
FOGED NIELS TAEKKER (DK)
JENSEN FLEMMING REISSIG (DK)
Application Number:
DK0300575W
Publication Date:
May 13, 2004
Filing Date:
September 04, 2003
Export Citation:
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Assignee:
NEUROSEARCH AS (DK)
DAHL BJARNE H (DK)
CHRISTOPHERSEN PALLE (DK)
ENGSIG MICHAEL THYRRING (DK)
KARSDAL MORTEN ASSER (DK)
FOGED NIELS TAEKKER (DK)
JENSEN FLEMMING REISSIG (DK)
International Classes:
C07D277/20; A61K31/17; A61K31/19; A61K31/192; A61K31/401; A61K31/41; A61K31/426; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/661; A61K31/69; A61P1/04; A61P1/12; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P11/06; A61P13/00; A61P17/00; A61P17/06; A61P17/08; A61P17/10; A61P19/00; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P35/04; A61P37/08; A61P43/00; C07C275/26; C07C275/30; C07C275/42; C07D207/16; C07D209/40; C07D213/75; C07D213/81; C07D213/82; C07D231/40; C07D257/04; C07D277/48; C07D295/192; C07D307/68; C07D333/36; C07D401/12; C07F5/02; C07F9/38; C07F9/58; (IPC1-7): C07C275/26; C07C275/28; C07D257/04; C07D207/00; A61K31/17; A61K31/41; A61P19/00; A61P43/00
Domestic Patent References:
WO2003000245A12003-01-03
WO2002039987A22002-05-23
WO1998047879A11998-10-29
WO2000024707A12000-05-04
WO1997045400A11997-12-04
WO2002064128A12002-08-22
WO1997045111A11997-12-04
WO1994022807A11994-10-13
WO2001012188A12001-02-22
WO2001076530A22001-10-18
WO2002092576A12002-11-21
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