Title:
DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO AΒ PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/140924
Kind Code:
A1
Abstract:
The present invention provides dihydrazone compounds having high affinity to Aβ protein and Tau protein and derivatives thereof. The structure of said compounds is as shown in formula (I): (I). Such compounds can be directly used as fluorescent probes for detecting neurofibrillary tangles in vivo or in a tissue sample, and when used in nuclear medicine imaging, the compounds need to be labelled using a suitable radioactive isotope. Such compounds are particularly useful for diagnosing patients with neurodegenerative diseases, including Alzheimer's disease, having the characteristics of Aβ plaques and neurofibrillary tangles.
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Inventors:
SHEN LANGTAO (CN)
CUI MENGCHAO (CN)
DENG XUESONG (CN)
ZHOU KAIXIANG (CN)
CUI MENGCHAO (CN)
DENG XUESONG (CN)
ZHOU KAIXIANG (CN)
Application Number:
PCT/CN2020/070009
Publication Date:
July 09, 2020
Filing Date:
January 02, 2020
Export Citation:
Assignee:
HTA CO LTD (CN)
UNIV BEIJING NORMAL (CN)
UNIV BEIJING NORMAL (CN)
International Classes:
C07C251/88
Domestic Patent References:
| WO2012027548A1 | 2012-03-01 |
Other References:
ANONYMOUS: "REGISTRY ANSWER 1-18", STN COLUMBUS, 24 June 2016 (2016-06-24), pages 1 - 14, XP009521828
WANG, JIA: "Research on Computer Aided Design of AD Molecular Imaging Probe", CHINESE MASTER’S THESES FULL-TEXT DATABASE, 31 December 2007 (2007-12-31), pages 1 - 48, XP009521821
WANG, JIA: "Research on Computer Aided Design of AD Molecular Imaging Probe", CHINESE MASTER’S THESES FULL-TEXT DATABASE, 31 December 2007 (2007-12-31), pages 1 - 48, XP009521821
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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