Title:
DIHYDROCHLORIDE OF INDAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/052873
Kind Code:
A1
Abstract:
Disclosed is a novel acid addition salt of an indazole derivative that is useful as an active ingredient for a pharmaceutical agent for preventing and/or treating diabetes, obesity, hyperlipemia, overactive bladder, urinary incontinence and the like, particularly a crystal of the acid addition salt, wherein the acid addition salt has desirable properties. Specifically disclosed is (R)-N-[3-[2-[2-(3- methylindazol-6-yloxy)ethylamino]-1-hydroxyethyl]phenyl] methanesulfonamide dihydrochloride or a crystal thereof. The crystal of the dihydrochloride may have the main peak at one or more positions selected from the group consisting of about 12.8˚, 21.8˚ and 25.0˚ 2θ in powdery X-ray diffraction spectra.
Inventors:
NAKANO SEIJI (JP)
IWANAMI TAISUKE (JP)
MAEHARA YASUHIKO (JP)
KIDA HITOSHI (JP)
IWANAMI TAISUKE (JP)
MAEHARA YASUHIKO (JP)
KIDA HITOSHI (JP)
Application Number:
PCT/JP2009/005774
Publication Date:
May 14, 2010
Filing Date:
October 30, 2009
Export Citation:
Assignee:
ASAHI KASEI PHARMA CORP (JP)
NAKANO SEIJI (JP)
IWANAMI TAISUKE (JP)
MAEHARA YASUHIKO (JP)
KIDA HITOSHI (JP)
NAKANO SEIJI (JP)
IWANAMI TAISUKE (JP)
MAEHARA YASUHIKO (JP)
KIDA HITOSHI (JP)
International Classes:
C07D231/54; A61K31/416; A61P13/10
Domestic Patent References:
| WO2003035620A1 | 2003-05-01 | |||
| WO2002060873A1 | 2002-08-08 | |||
| WO2007063821A1 | 2007-06-07 |
Attorney, Agent or Firm:
IWASE, Yoshikazu et al. (JP)
Yoshikazu Iwase (JP)
Yoshikazu Iwase (JP)
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