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Title:
DIHYDROISOQUINOLINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/130152
Kind Code:
A1
Abstract:
The present invention provides a compound of general formula I: formula I, in which R is any one of hydrogen, and C1-6 alkyl; R1 is any one of hydrogen, deuterium, halogen, C1-6 alkyl, C1-6 alkylamino, and C1-6 alkoxy; R2 is any one of hydrogen, deuterium, halogen, C1-6 alkyl, C1-6 alkyl substituted by at least one fluorine, C3-7 cycloalkyl, C1-6 alkylamino, C1-6 alkoxy, and heterocycloalkyl; Ar is phenyl, thienyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, pyridin-2(1H)-one group, pyridin-4(1H)-one group, pyrrolyl, pyrazolyl, thiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, imidazolyl, tetrazolyl, isothiazolyl, oxazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, naphthyl, benzothiophenyl, indolyl, benzimidazolyl, benzothiazolyl, benzofuranyl, quinolinyl, isoquinolinyl, and quinazolinyl; R3 is any one of hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkylamino, C1-6 alkoxy, and heterocycloalkyl; R4 is any one of hydrogen, deuterium, and C1-6 alkyl; and R5 is any one of hydrogen, deuterium, C1-6 alkyl, C1-6 alkyl substituted by at least one fluorine, and C3-7 cycloalkyl. The compound provided in the present invention can be used for treating and preventing hepatitis B virus infection.

Inventors:
PENG CHENG (CN)
XU QING (CN)
FENG TENG (CN)
LV XIASHI (CN)
LAI XIAOGANG (CN)
CUI RUI (CN)
ZHANG SHAOYUN (CN)
HAN JIAN (CN)
GONG CHAOJUN (CN)
CAI ZHAOXIONG (CN)
ZHOU YANG (CN)
ZOU GANG (CN)
LI DANBIN (CN)
YUAN HAIQING (CN)
WU ZHEN JIM (CN)
Application Number:
PCT/CN2018/072057
Publication Date:
July 19, 2018
Filing Date:
January 10, 2018
Export Citation:
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Assignee:
SUZHOU ARK BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D455/06; A61P1/16; A61P31/20
Domestic Patent References:
WO2015173164A12015-11-19
Foreign References:
CN106810548A2017-06-09
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