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Title:
DIRECT STEREOSPECIFIC SYNTHESIS OF UNPROTECTED AZIRIDINES FROM OLEFINS
Document Type and Number:
WIPO Patent Application WO/2015/103505
Kind Code:
A3
Abstract:
A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N-H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal catalyst. The method is operationally simple (i.e., one-pot), scalable and fast at ambient temperature.

Inventors:
ESS DANIEL HALSELL (US)
FALCK JOHN RUSSELL (US)
JAT JAWAHAR LAL (IN)
URTI LASZLO (US)
Application Number:
PCT/US2015/010076
Publication Date:
July 30, 2015
Filing Date:
January 03, 2015
Export Citation:
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Assignee:
ESS DANIEL HALSELL (US)
FALCK JOHN RUSSELL (US)
JAT JAWAHAR LAL (IN)
URTI LASZLO (US)
International Classes:
C07D203/26; C07D275/06; C07D403/02
Foreign References:
US6008376A1999-12-28
Other References:
LEBEL ET AL.: "Copper-Catalyzed Alkene Aziridination with N-Tosyloxycarbamates", ORGANIC LETTERS, vol. 9, no. 23, 2007, pages 4797 - 4800, XP055214190
CATINO ET AL.: "Efficient Aziridination of Olefins Catalyzed by Mixed-Valent Dirhodium(II,III) Caprolactamate", ORGANIC LETTERS, vol. 7, no. 13, 2005, pages 2787 - 2790, XP055214191
GAUCHER ET AL.: "Fluorous Tagged N-Hydroxy Phthalimide for the Parallel Synthesis of O- Aryloxyamines", J COMB CHEM., vol. 12, no. 5, 2010, pages 655 - 658, XP055214195
Attorney, Agent or Firm:
MARSHALL, Ryan, L. et al. (P.O. Box 10087Chicago, IL, US)
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