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Title:
DRUG FOR ANTAGONIZING REPLICATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/068533
Kind Code:
A1
Abstract:
A drug for antagonizing the replication of porcine reproductive and respiratory syndrome virus (PRRSV) and an application thereof. By using a viral infection test, a drug which antagonizes PRRSV - xanthohumol - is discovered for the first time from among a natural drug library of 386 plant sources. Xanthohumol can effectively inhibit PRRSV replication on both Marc-145 and PAM cells. Five xanthohumol derivatives having different molecular structures are artificially synthesized, and it is discovered that a derivative Xn-4 has the strongest inhibitory effect on virus replication in vitro. Test results of artificial infection and drug therapy in piglets show that the Xn-4 can effectively inhibit PRRSV viremia, relieve clinical symptoms of infected pigs, and significantly reduce lung inflammation and pathological damage.

Inventors:
JIANG PING (CN)
LIU XUEWEI (CN)
BAI JUAN (CN)
ZHANG JUNREN (CN)
WANG XIANWEI (CN)
LI YUFENG (CN)
Application Number:
PCT/CN2020/094179
Publication Date:
April 15, 2021
Filing Date:
June 03, 2020
Export Citation:
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Assignee:
UNIV NANJING AGRICULTURAL (CN)
International Classes:
A61P11/00; A61K31/12; A61P31/14; C07C45/74; C07C49/84
Foreign References:
CN110613706A2019-12-27
KR20150049695A2015-05-08
CN108524476A2018-09-14
Other References:
LIU XUEWEI; BAI JUAN; JIANG CHENLONG; SONG ZHONGBAO; ZHAO YONGXIANG; NAUWYNCK HANS; JIANG PING: "Therapeutic effect of Xanthohumol against highly pathogenic porcine reproductive and respiratory syndrome viruses", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 238, 26 September 2019 (2019-09-26), NL, XP085876340, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2019.108431
ZHANG FANGJIE, LI YULIN: "Synthesis of 4′--Hydroxy--5, 7--dimethoxy--3′, 8--diallylflavanone", JOURNAL OF LANZHOU UNIVERSITY, SCIENCE EDITION, vol. 27, no. 4, 1 January 1991 (1991-01-01), pages 91 - 93, XP055798749, DOI: 10.13885/j.issn.0455-2059.1991.04.016
SEKIZAKI HARUO, YOKOSAWA RYOZO: "Studies on Zoospore-Attracting Activity.I.Synthesis of Isoflavones and Their Attracting Activity to Aphanomyces euteiches Zoospore", CHEM. PHARM. BULL, vol. 36, 1 January 1988 (1988-01-01), pages 4876 - 4880, XP055798741
LI RONG, HOU YAN-JUN, ZHOU QIANG, SUN ZHI-ZHONG: "Total synthesis of Genkwanin", JOURNAL OF NATURAL SCIENCE OF HEILONGJIANG UNIVERSITY, vol. 27, no. 4, 1 August 2010 (2010-08-01), pages 504 - 511, XP055798752, DOI: 10.13482/j.issn1001-7011.2010.04.022
CHOI DAHEUI, PARK JIN CHAN, LEE HA NA, MOON JI-HOI, AHN HYO-WON, PARK KWANGYONG, HONG JINKEE: "In Vitro Osteogenic Differentiation and Antibacterial Potentials of Chalcone Derivatives", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 8, 6 August 2018 (2018-08-06), US, pages 3197 - 3204, XP055798744, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.8b00288
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
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