Title:
DRUG COMPOSITION CONTAINING NF-κB INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2004/002465
Kind Code:
A1
Abstract:
A drug composition for ameliorating the symptoms attributed to tumor cells, comprising a compound represented by the general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient. General formula: (1) wherein R1 represents hydrogen or a C2-4 alkanoyl group; and R2 represents a group of any of the following formulae: (A) - (G) in which R3 represents a C1-4 alkyl group.
Inventors:
UMEZAWA KAZUO (JP)
KAWAI YOHKO (JP)
HORIE RYOUICHI (JP)
WATANABE TOSHIKI (JP)
TOI MASAKAZU (JP)
MATSUMOTO GAKU (JP)
HORIGUCHI YUTAKA (JP)
NAKASHIMA JUN (JP)
KAWAI YOHKO (JP)
HORIE RYOUICHI (JP)
WATANABE TOSHIKI (JP)
TOI MASAKAZU (JP)
MATSUMOTO GAKU (JP)
HORIGUCHI YUTAKA (JP)
NAKASHIMA JUN (JP)
Application Number:
PCT/JP2003/008134
Publication Date:
January 08, 2004
Filing Date:
June 26, 2003
Export Citation:
Assignee:
UNIV KEIO (JP)
UMEZAWA KAZUO (JP)
KAWAI YOHKO (JP)
HORIE RYOUICHI (JP)
WATANABE TOSHIKI (JP)
TOI MASAKAZU (JP)
MATSUMOTO GAKU (JP)
HORIGUCHI YUTAKA (JP)
NAKASHIMA JUN (JP)
UMEZAWA KAZUO (JP)
KAWAI YOHKO (JP)
HORIE RYOUICHI (JP)
WATANABE TOSHIKI (JP)
TOI MASAKAZU (JP)
MATSUMOTO GAKU (JP)
HORIGUCHI YUTAKA (JP)
NAKASHIMA JUN (JP)
International Classes:
A61K31/167; A61K31/336; A61P9/10; A61P35/00; A61P35/04; A61P43/00; (IPC1-7): A61K31/167; A61K45/00; A61K31/336; A61P9/10; A61P35/00; A61P35/04; A61P43/00
Domestic Patent References:
| WO2001012588A1 | 2001-02-22 | |||
| WO2002049632A1 | 2002-06-27 |
Other References:
KAZUO UMEZAWA: "Tensha inshi NF-kappaB no yakuwari to sogaizai", SURGERY FRONTIER, vol. 9, no. 2, 1 June 2002 (2002-06-01), pages 88 - 91, XP002973376
MATSUMOTO N.: "Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C", BIOORG. MED. CHEM. LETT., vol. 10, no. 9, 2000, pages 865 - 869, XP002934325
ASEA A.: "Novel signal transduction pathway utilized by extracellular HSP70. Role of toll-like receptor (TLR) 2 and TLR4", J. BIOL. CHEM., vol. 277, no. 17, 26 April 2002 (2002-04-26), pages 15028 - 15034, XP002971859
YAN Z.: "Benzo(a)pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extra-cellular signal-regulated kinase and NF-kappaB", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 7, 18 February 2000 (2000-02-18), pages 4949 - 4955, XP002971860
KEIICHI HISHIKAWA: "NF-kappa B as a therapeutic drug target", FOLIA PHARMACOLOGICA JAPONICA, vol. 118, no. 3, 2001, pages 197 - 202, XP002971861
See also references of EP 1541139A4
MATSUMOTO N.: "Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C", BIOORG. MED. CHEM. LETT., vol. 10, no. 9, 2000, pages 865 - 869, XP002934325
ASEA A.: "Novel signal transduction pathway utilized by extracellular HSP70. Role of toll-like receptor (TLR) 2 and TLR4", J. BIOL. CHEM., vol. 277, no. 17, 26 April 2002 (2002-04-26), pages 15028 - 15034, XP002971859
YAN Z.: "Benzo(a)pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extra-cellular signal-regulated kinase and NF-kappaB", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 7, 18 February 2000 (2000-02-18), pages 4949 - 4955, XP002971860
KEIICHI HISHIKAWA: "NF-kappa B as a therapeutic drug target", FOLIA PHARMACOLOGICA JAPONICA, vol. 118, no. 3, 2001, pages 197 - 202, XP002971861
See also references of EP 1541139A4
Attorney, Agent or Firm:
ISSHIKI & CO. (12-7 Shinbashi 2-chom, Minato-ku Tokyo, JP)
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