Title:
DRUG CONTAINING METHOTREXATE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1996/030019
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) or salts thereof, (wherein R1 represents a member selected from the group consisting of CH2, CH2CH2, CH2O, CH2S and CH2SO; R2 represents hydrogen, lower (C1-4) alkyl or benzyl; R3 represents COOR4, NHCOR5, CONR6R7, PO3H2 or SO3H; and n is an integer of from 1 to 4) which are useful as a remedy for autoimmune diseases such as systemic lupus erythematosus or nephritis such as glomerulonephritis.
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Inventors:
MIHARA MASAHIKO (JP)
Application Number:
PCT/JP1996/000780
Publication Date:
October 03, 1996
Filing Date:
March 26, 1996
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
MIHARA MASAHIKO (JP)
MIHARA MASAHIKO (JP)
International Classes:
A61K31/519; A61K31/5415; C07D475/08; (IPC1-7): A61K31/505; C07D475/08
Domestic Patent References:
| WO1992003436A1 | 1992-03-05 | |||
| WO1994014810A1 | 1994-07-07 |
Foreign References:
| JPH0616558A | 1994-01-25 |
Other References:
See also references of EP 0818199A4
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