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Patent Searching and Data


Title:
DRUG DELIVERY SYSTEM OF SUBSTITUTED HYDROXYPYRIDINE COMPOUND AND CONJUGATE OF HYDROXYPYRIDINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2004/005259
Kind Code:
A1
Abstract:
A drug delivery system of a substituted hydroxypyridine compound which comprises: i) orally administering the substituted hydroxypyridine compound, ii) converting the substituted hydroxypyridine compound into a conjugate during the absorption step in vivo, and iii) delivering the conjugate to a target tissue; and a conjugate of a substituted hydroxypyridine compound to be used in this drug delivery system. Because of having a potent PDE IV inhibitory effect and an excellent bronchodilation effect, the conjugate to be used in the above-described drug delivery system is widely useful as a PDE IV inhibitor in remedies and preventives for allergic inflammatory diseases, tissue inflammatory diseases, etc.

Inventors:
TERANISHI YASUHIRO (JP)
NAKAMURA SHUNYA (JP)
NIGO TOMOHIRO (JP)
NISHIMURA NAOHIRO (JP)
KONDO KAORI (JP)
TODA HIROSHI (JP)
MISE MASASHI (JP)
MIZUKI YASUYUKI (JP)
MATSUMOTO SATOSHI (JP)
ITOH MARI (JP)
Application Number:
PCT/JP2003/008462
Publication Date:
January 15, 2004
Filing Date:
July 03, 2003
Export Citation:
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Assignee:
DAINIPPON PHARMACEUTICAL CO (JP)
TERANISHI YASUHIRO (JP)
NAKAMURA SHUNYA (JP)
NIGO TOMOHIRO (JP)
NISHIMURA NAOHIRO (JP)
KONDO KAORI (JP)
TODA HIROSHI (JP)
MISE MASASHI (JP)
MIZUKI YASUYUKI (JP)
MATSUMOTO SATOSHI (JP)
ITOH MARI (JP)
International Classes:
A61K31/444; A61K31/706; A61P11/00; A61P11/06; A61P11/08; A61P29/00; A61P43/00; C07H17/02; C07H19/048; (IPC1-7): C07D213/69; C07H17/02; C07H19/048; A61K31/444; A61K31/706; A61P11/00; A61P11/06; A61P11/08; A61P29/00; A61P43/00
Foreign References:
EP1120409A12001-08-01
US5629011A1997-05-13
Other References:
HIROSHI KANETO ET AL., JAPANESE JOURNAL OF OCULAR PHARMACOLOGY, KABUSHIKI KAISHA HIROKAWA SHOTEN, 15 April 1986 (1986-04-15), pages 23 - 30, XP002972278
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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