Title:
DYNAMIC ORGAN FUNCTION MONITORING AGENTS
Document Type and Number:
WIPO Patent Application WO2002032860
Kind Code:
A3
Abstract:
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible regionof light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
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Inventors:
ACHILEFU SAMUEL (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
JIMENEZ HERMO N (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
JIMENEZ HERMO N (US)
Application Number:
PCT/US2001/031716
Publication Date:
October 17, 2002
Filing Date:
October 05, 2001
Export Citation:
Assignee:
MALLINCKRODT INC (US)
ACHILEFU SAMUEL (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
JIMENEZ HERMO N (US)
ACHILEFU SAMUEL (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
JIMENEZ HERMO N (US)
International Classes:
C07H15/26; A61K49/00; C07D209/08; C07D209/12; C07D209/60; C07D405/14; (IPC1-7): A61K51/00; A61M36/14
Foreign References:
| US6027709A | 2000-02-22 | |||
| US6083485A | 2000-07-04 |
Other References:
See also references of EP 1326651A4
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