Title:
DYNEIN BINDING PEPTIDE CAPABLE OF PERMEATING THROUGH BIOLOGICAL BARRIER, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/156531
Kind Code:
A1
Abstract:
Disclosed are a dynein binding peptide capable of permeating through a biological barrier, and the use thereof. The polypeptide provided by the present invention is a polypeptide A or a polypeptide B, wherein the polypeptide A is sequentially composed of a core region A and a cell-penetrating peptide from the N-terminus to the C-terminus, and the amino acid sequence of the core region A is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4; and the polypeptide B is sequentially composed of a core region B and a cell-penetrating peptide from the N-terminus to the C-terminus, and the amino acid sequence of the core region B is SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8. According to the present invention, the polypeptide A can achieve intracellular perinuclear delivery, the polypeptide B can achieve intracellular intranuclear delivery, and the two polypeptides both have biological barrier permeability.
Inventors:
ZHENG AIPING (CN)
LIU NAN (CN)
WANG ZENGMING (CN)
ZHANG HUI (CN)
GAO JING (CN)
GAO XIANG (CN)
DU YIMENG (CN)
LV JIAQI (CN)
LIU NAN (CN)
WANG ZENGMING (CN)
ZHANG HUI (CN)
GAO JING (CN)
GAO XIANG (CN)
DU YIMENG (CN)
LV JIAQI (CN)
Application Number:
PCT/CN2022/070230
Publication Date:
July 28, 2022
Filing Date:
January 05, 2022
Export Citation:
Assignee:
ACAD OF MILITARY MEDICAL SCIENCES AMS PLA (CN)
International Classes:
C07K19/00; A61K38/00; A61K47/64; C07K7/06; C07K7/08
Domestic Patent References:
WO2020206189A1 | 2020-10-08 | |||
WO2020017496A1 | 2020-01-23 | |||
WO1998020887A1 | 1998-05-22 |
Foreign References:
US20180346531A1 | 2018-12-06 | |||
US20040132970A1 | 2004-07-08 | |||
US20200206304A1 | 2020-07-02 | |||
CN101412747A | 2009-04-22 | |||
CN101160403A | 2008-04-09 | |||
AU2012204135A1 | 2012-08-02 | |||
CN103626850A | 2014-03-12 | |||
CN111182913A | 2020-05-19 | |||
CN105050612A | 2015-11-11 |
Attorney, Agent or Firm:
JEEKAI&PARTNERS (CN)
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