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Title:
ECTEINASCIDINS 729, 743, 745, 759A, 759B AND 770
Document Type and Number:
WIPO Patent Application WO/1987/007610
Kind Code:
A2
Abstract:
Novel compounds ecteinascidins 729, 743, 745, 759A, 759B, and 770 having antibacterial and antitumor properties.

Inventors:
RINEHART KENNETH L (US)
HOLT TOM G (US)
Application Number:
PCT/US1987/001226
Publication Date:
December 17, 1987
Filing Date:
June 01, 1987
Export Citation:
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Assignee:
UNIV ILLINOIS (US)
International Classes:
A61K31/495; A61K35/00; A61K35/56; A61K35/655; A61P31/04; C07D515/22; C07G11/00; (IPC1-7): C07G11/00; A61K35/00
Other References:
Biological Abstracts, Vol. 81, 1986 (Phila., PA, US) T. SASAKI et al.: "Antitumor Activity of Aqueous Extracts of Marine Animals", see Abstract No. 103819, & J. Pharmacobio-Dyn 8(11), 969-974, 1985
Biological Abstracts, Vol. 78, 1984 (Phila., PA, US) J.F. DAVIS et al.: "The Enhancement of Resistance of the American Cel, Anguilla Rostrata, to a Pathogenic Bacterium, Aeromonas Hydrophila, by an Extract of the Tunicate Ecteinascidia Turbinata", see Abstract No. 75713, & J. Fish Dis 7(4): 311-316, 1984
CHEMICAL ABSTRACTS, Vol. 102, 1985 (Columbus, Ohio, US) M. SIGEL et al.: "A Substance from the Marine Tunicate Ecteinascidia Turbinata with Selective Action on Macrophages", see page 535, Abstract No. 111299y, & Immunol. Ser. 1984, 26(Mononucl. Phagocyte Biol.), 451-71
CHEMICAL ABSTRACTS, Vol. 80, 1974 (Columbus, Ohio, US) W. LICHTER et al.: "Biological Activities Exerted by Extracts of Ecteinascidia Turbinata", see page 16, Abstract No. 91215q & Food-Drugs Sea, Proc. (Conf.) 3rd 1972 (pub. 1973), 117-27
CHEMICAL ABSTRACTS, Vol. 84, 1976 (Columbus, Ohio, US) W. LICHTER et al.: "Ecteinascidia Turbinata Extracts Inhibit DNA Synthesis in Lymphocytes after Mitogenic Stimulation by Lectins" see page 95, Abstract No. 13069p, & Proc. Soc. Exp. Biol. Med. 1975, 150(2), 475-8
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