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Title:
ELECTROSPUN-COATED MEDICAL DEVICES
Document Type and Number:
WIPO Patent Application WO/2019/138412
Kind Code:
A1
Abstract:
Compositions comprising electrospun fibers and pharmaceutical agents encapsulated thereto are provided. Further, articles such as medical devices and methods of use of said fibers, including, but not limited to coating of medical tubes, are provided.

Inventors:
ZUSSMAN EYAL (IL)
ABU AMMAR AIMAN (IL)
GRUBER MAAYAN (IL)
Application Number:
PCT/IL2019/050057
Publication Date:
July 18, 2019
Filing Date:
January 15, 2019
Export Citation:
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Assignee:
TECHNION RES & DEV FOUNDATION (IL)
HEALTH CORP OF GALILEE MEDICAL CENTER (IL)
International Classes:
A61L27/54; A61K9/70; A61L27/56; A61L27/58; A61L29/08; A61L29/16; A61L33/00; C09D7/63; D01D5/00; D01F8/04; D04H1/728
Domestic Patent References:
WO2017156521A12017-09-14
WO2009101472A22009-08-20
Foreign References:
KR20150083732A2015-07-20
Other References:
ABU AMMAR A. ET AL.: "Local delivery of mometasone furoate from an eluting endotracheal tube", JOURNAL OF CONTROLLED RELEASE, vol. 272, 10 January 2018 (2018-01-10), pages 54 - 61, XP055624988, ISSN: 0168-3659
GAO Q. ET AL.: "Fabrication and characterization of metal stent coating with drug-loaded nanofiber film for gallstone dissolution", JOURNAL OF BIOMATERIALS APPLICATIONS, vol. 31, no. 5, 3 October 2016 (2016-10-03), pages 784 - 796, XP009521756, ISSN: 1530-8022
ZHU Y. ET AL.: "A highly flexible paclitaxel-loaded poly(ε-caprolactone) electrospun fibrous- membrane-covered stent for benign cardia stricture", ACTA BIOMATERIALIA, vol. 9, no. 9, 13 June 2013 (2013-06-13), pages 8328 - 8336, XP055624998, ISSN: 1742-7061
PARK C.G. ET AL.: "Polymeric nanofiber coated esophageal stent for sustained delivery of an anticancer drug", MACROMOLECULAR RESEARCH, vol. 19, no. 11, 1 October 2011 (2011-10-01), pages 1210 - 1216, XP055624996, ISSN: 2092-7673
CHAO Y.K. ET AL.: "Sustained release of bactericidal concentrations of penicillin in the pleural space via an antibiotic-eluting pigtail catheter coated with electrospun nanofibers: results from in vivo and in vitro studies", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 10, no. 1, 4 May 2015 (2015-05-04), pages 3329 - 3336, XP055625003, ISSN: 1178-2013
SONG W. ET AL.: "Coaxial PCL/PVA electrospun nanofibers: osseointegration enhancer and controlled drug release device", BIOFABRICATION, vol. 5, no. 3, 25 June 2013 (2013-06-25), pages 35006, XP055621618, ISSN: 1758-5090
See also references of EP 3740255A4
Attorney, Agent or Firm:
KESTEN, Dov et al. (IL)
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