BACKGROUND OF THE INVENTION The present invention is directed to a process for the enantioselective production of compounds. In particular, the invention is directed to a method for the enantioselective hydrogenation of compounds of use in the production of pharmaceutically active compounds, especially compounds which are useful as activators of glucokinase for the treatment of type II diabetes. Methods for the enantioselective hydrogenation of functionalized olefins, ketones and imines are known in the art. However, the enantioselective hydrogenation of 2-substituted acrylic acids has proved less successful than the enantioselective hydrogenation of other starting materials, such as α-enamides, as the substituent in the 2-position has a considerable impact on the degree of enantioselectivity that can be achieved. The purity of pharmaceutical compounds to be used for methods of treatment is of paramount importance, thus for example, the synthesis of pharmaceutically active compounds of high enantiomeric purity on a commercial scale is a challenge for the pharmaceutical industry. International Patent Application PCT/US04/03968 (published after the priority date of the present application) discloses various tri(cyclo) substituted amide compounds which are modulators of glucokinase and are useful in the prophylactic or therapeutic treatment of hyperglycemia and diabetes, in particular type II diabetes. Certain of these compounds, for example (2i?)-2-(4-cyclobutanesulfonyl phenyl)-N-pyrazin-2-yl-3 -(tetrahydropyran-4- yl)propionamide, (2i?)-2-(4-cyclobutanesulfonylphenyl)-N-( 1 -methyl- lH-pyrazol-3 -yl)-3 - (tetrahydropyran-4-yl)propionamide, (2/?)-2-(4-cyclobutanesulfonylphenyl)-N-(5- fluorothiazol-2-yl)-3-(tetrahydropyran-4-yl)propionamide, (2i?)-2-(4- cyclopropanesulfonylphenyl)-N-(5-fluorothiazol-2-yl)-3-(tetr ahydropyran-4-yl)propionamide and (2i?)-2-(4-cyclopropanesulfonylphenyl)-N-pyrazin-2-yl-3-(tet rahydropyran-4- yl)propionamide, have a chiral center thus there is a need for efficient processes for the production of such compounds of high enantiomeric purity. PCT/US04/03968 describes the synthesis of such compounds by condensation of the corresponding chiral acid: for example where R is cyclobutyl or cyclopropyl, and the corresponding heteroaromatic amine. The (22?)-propionic acid compound is produced from the corresponding racemic acid i.e. 2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-yl)pro pionic acid or 2-(4- cyclobutanesulfonylphenyl)-3-(teti-aliydropyran-4-yl)propion ic acid by condensing with a chiral oxazolidinone derivative to generate a mixture of diastereoisomeric imides that are separable by any conventional method, e.g. column chromatography. Hydrolysis of the pure imides affords the stereopure (2R)-propionic acids that can then be condensed with heterocyclic amines employing a reagent that minimises racemisation of the chiral centre, e.g. benzotriazol- 1 -yloxytris(pyrrolidino)phosphonium hexafluorophosphate . However, this process is not particularly efficient for the synthesis of such compounds on a commercial scale. Therefore there is a need for further efficient processes for the production of such compounds of high enantiomeric purity and yield.

SUMMARY OF THE INVENTION A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.

DETAILED DESCRIPTION OF THE INVENTION The present invention provides a process for the production of a compound of formula (I):

(I) wherein R is cyclopropyl or cyclobutyl, comprising the enantioselective hydrogenation of a compound of formula (II):

(H) wherein the double bond is in the (E)-configuration and R is cyclopropyl or cyclobutyl. The hydrogenation of the compounds of formula (II) is preferably conducted in the presence of a rhodium or ruthenium catalyst. The catalyst is preferably an anionic, neutral or cationic rhodium catalyst, more preferably a cationic rhodium catalyst. The catalyst is preferably generated in situ, for example from [Rh(nbd)2]BF4, [Rh(nbd)Cl]2, or [RuI2(p- cymeme)]2 and a suitable ligand (nbd = norbornadiene). Alternatively the catalyst may be isolated before use. Suitable ligands include diphosphine and phosphine ligands, preferably atropisomeric diphosphines, which may have additionally a chiral carbon atom (see M. Scalone Tetrahedron Asymmetry, 1997, 8, 3617; T. Uemura, J. Org. Chem., 1996, 61, 5510; and X. Zhang Synlett, 1994, 501), chiral diphosphine ligands such as for example Josiphos (EP-A-0612758), Walphos (F. Spindler, Adv. Synth. Catal., 2003, 345,1; EP-A-I 1236994; and US-6777567), Phospholane (CH0813/03), Mandyphos (EP-A-0965574; DE-A-I 19921924; and DE-A-I 19956374), Taniaphos (DE-A-I 19952348) and other ferrocene ligands such as for example Jafaphos (EP-Al-803510). Particularly preferred are ferrocene ligands, for example Mandyphos ligands as described in EP-A-965574. Preferred Mandyphos ligands have the structure:

wherein G and G' which may be the same or different are selected from phenyl optionally substituted with one or more substituents selected from C^alkyl and methoxy, e.g. 2-MePh, 3,5-diMePh or 3,5-diMe-4-MeOPh; R is phenyl or methyl, e.g. phenyl; and R' are independently selected from e.g. methyl. Particular Mandyphos ligands which may be mentioned include (R)-(S)-MOD- Mandyphos and xyl-Mandyphos, especially (R)-(S)-MOD-Mandyphos (structure shown below):

(R)-(S)-MOD-Mandyphos

A particularly preferred catalyst/ligand combination is [Rh(nbd)2]BF4 / (R)-(S)-MOD- Mandyphos. The hydrogenation pressure used in the process of the invention is preferably up to about 100 bar, such as in the range of 5-100 bar, such as 5-50 bar, for example 15-50 bar. The temperature used in the process of the invention is preferably up to about 1000C, such as in the range of room temperature to 8O0C, e.g. 30-800C, preferably about 3O0C. The process of the invention is preferably conducted in solution. Suitable solvents include alcoholic solvents, for example methanol, ethanol and iso-propanol. It is particularly preferred that a mixed solvent is used, for example, a mixture of an alcoholic solvent and an arene solvent, e.g. benzene or toluene, preferably toluene, or a mixture of an alcoholic solvent and dimethoxyether, trifluoroethanol or dichloromethane. Suitable mixed solvents include mixtures of alcoholic solvents and toluene, e.g. methanol and toluene. A preferred solvent mixture is 1:1 to 10:lv/v methanol:toluene, especially about 5:lv/v methanobtoluene. A further preferred solvent mixture is 1:1 to 10: lv/v ethanol:toluene, especially about 5:lv/v ethanolrtoluene. The process of the invention may also be conducted in the presence of base additives e.g. KOH or amines such as NEt3. A preferred base additive is NEt3 which may be added to the hydrogenation mixture in an amount of about lOeq/Rh or Ru. The (i?)-acid of formula (I) may also be further enantiomerically enriched, e.g. by recrystallisation. Suitable solvents for recrystalisation include isopropylacetate, isobutylacetate and ethylacetate, preferably isobutylacetate and mixed solvents such as isobutylacetate or ethylacetate and heptane. A preferred solvent mixture is isobutyl acetate and heptane at a ratio of 20:1 to l:lv/v e.g. 9:lv/v. Other solvents include wateπacetic acid e.g. l:lv/v, and 1-butanol. The (i?)-acid of formula (I) produced according to the process of the invention preferably has >85% ee, more preferably >90% ee, even more preferably >95% ee, and especially >98% ee. The (E)-acids of formula (II) may be prepared as described in the Examples, or by processes analogous thereto. The (E)-acid of formula (II) used in the method of the invention should be as pure as possible. The (E)-acid of formula (II) is preferably washed with water prior to its use as a substrate in the hydrogenation reaction e.g. to remove any chloride ions which may be present. The invention also provides the use of the compounds of formula (I) prepared as described above as an intermediate for the manufacture of a compound of formula (III), or a pharmaceutically acceptable salt thereof:

(HI) wherein R is cyclopropyl or cyclobutyl; T together with the -N=C- to which it is attached forms a heteroaryl ring, or a heterocyclic ring where the N=C bond is the only site of unsaturation; R3 and R4 each independently are hydrogen, halogen, OCFnH3_n, methoxy, CO2R5, cyano, nitro, CHO, CONR6R7, CON(OCH3)CH3, or C^alkyl, heteroaryl, or C3_7cycloalkyl optionally substituted with 1-5 independent halogen, hydroxy, cyano, methoxy, -NHCO2CH3, or -N(Co_2alkyl)(Co-2alkyl) substituents; or R3 and R4 together form a 5-8-membered aromatic, heteroaromatic, carbocyclic, or heterocyclic ring; R5 is hydrogen, or a group, C2-4alkenyl group, C2-4alkynyl group, C3- vcycloalkyl group, aryl group, heteroaryl group, or 4-7-membered heterocyclic group, wherein any group optionally is substituted with 1-6 independent halogen, cyano, nitro, hydroxy, C^alkoxy, -N(C0-2alkyl)(C0-2alkyl), Ci_2alkyl, C3_7cycloalkyl, 4-7-membered heterocyclic ring, CFnH3_n, aryl, heteroaryl, CO2H, -COC1_2alkyl, -CON(C0-2alkyl)(Co- 2alkyl), SOCH3, SO2CH3, or -S02N(C0-2alkyl)(Co_2alkyl) substituents; R6 and R7 each independently are hydrogen, or Ci-4alkyl group, C3-7cycloalkyl group, aryl group, heteroaryl group, or 4-7-membered heterocyclic group, wherein any group optionally is substituted with 1-6 independent halogen, cyano, nitro, hydroxy, Ci_2alkoxy, - N(Co-2alkyiχCo-2alkyl), Ci_2alkyl, C3_7cycloalkyl, 4-7-membered heterocyclic ring, CFnH3-.,,, aryl, heteroaryl, COCwalkyl, -CON(C0-2alkyl)(C0_2alkyl), SOCH3, SO2CH3, or -SO2N(C0- 2alkyl)(C0-2alkyl) substituents; or R6 and R7 together form a 6-8-membered heterobicyclic ring system or a 4-8-membered heterocyclic ring which optionally is substituted with 1-2 independent Ci_2alkyl, CH2OCH3, COC0_2alkyl, hydroxy, or SO2CH3 substituents; and n is 1, 2 or 3. The compounds of formula (III) may be prepared by the condensation of the carboxylic acid of formula (I) with an amine of formula (IV), or a salt thereof:

(IV) wherein R3 and R4 are as defined above, using a variety of coupling conditions, e.g. polymer supported carbodiimide- 1 -hydroxybenzotriazole in N,N-dimethylformamide at 200C (for representative procedures, see http://www.argotech.com/PDF/resins/ps_cai-bodiimide.pdf and available from Argonaut Technologies, Inc., Foster City, California). Alternatively, a compound of formula (III) may be prepared by condensing amine (IV), or a salt thereof, with an activated acid derivative, such as the corresponding acid chloride. Preferably the condensation is performed employing a reagent that minimises racemisation of the chiral centre, e.g. benzotriazol-l-yloxytris(pyrrolidino)phosphonium hexafluorophosphate (J. Coste et al. Tetrahedron Lett. 1990, 31, 205-208), to furnish enantiopure (i?)-amides of formula (HI). Alternatively the coupling reaction may employ an activated derivative of the carboxylic acid of formula (IV), for example a protected ester or acid chloride thereof which may be prepared by methods known to those skilled in the art, in which case the coupling may be conducted in the presence of collidine or another suitable pyridine derivative. The acid chloride derivatives of the compounds of formula (I) are novel. Thus according to a further aspect of the invention there is provided a compound of formula (V):

(V) wherein R is cyclopropyl or cyclobutyl. The acid chlorides of formula (V) may be prepared from the corresponding acids of formula (I) by methods known in the art. The acid chloride may be prepared for example by reaction of the compounds of formula (I) with oxalyl chloride or thionyl chloride in a suitable solvent, such as dichloromethane. The acid chloride may be isolated but is preferably generated in situ prior to coupling with an amine of formula (IV). Preferred compounds of formula (III) prepared according to this aspect of the invention include those compounds wherein T together with the -N=C- to which it is attached forms a 2-pyrazinyl or 2-thiazolyl ring, and R3 and R4 each independently are hydrogen, methyl or fluoro. In particular compounds wherein T together with the -N=C- to which it is attached forms a 5-fluorothiazol-2-yl group. In another embodiment of the invention, compounds of formula (III) include those compounds wherein T together with the -N=C- to which it is attached forms form a 3-pyrazolyl ring, wherein R and R4 are independently hydrogen or Ci-2alkyl, for example a l-methylpyrazol-3-yl group. The invention also provides a pharmaceutical composition comprising a compound of formula (III), or a pharmaceutically acceptable salt thereof, produced according to the method described above, in combination with a pharmaceutically acceptable diluent or carrier. The invention also provides a method of prophylactic or therapeutic treatment of a condition where activation of glucokinase is desirable comprising a step of administering an effective amount of a compound of formula (III), produced according to the method described above, or a pharmaceutically acceptable salt thereof. The invention also provides a method of prophylactic or therapeutic treatment of hyperglycemia or diabetes, particularly type II diabetes, comprising a step of administering an effective amount of a compound of formula (III), produced according to the method described above, or a pharmaceutically acceptable salt thereof. In this aspect of the invention the compound of formula (III) may be administered in combination with one or more other anti- hyperglycemic agents or anti-diabetic agents. The invention also provides a method of prevention of diabetes, particularly type II diabetes, in a human demonstrating pre-diabetic hyperglycemia or impaired glucose tolerance comprising a step of administering an effective prophylactic amount of a compound of formula (III), produced according to the method described above, or a pharmaceutically acceptable salt thereof. All publications, including, but not limited to, patents and patent application cited in this specification, are herein incorporated by reference as if each individual publication were specifically and individually indicated to be incorporated by reference herein as fully set forth. The invention will now be described by reference to the following examples which are for illustrative purposes and are not to be construed as a limitation of the scope of the present invention. EXAMPLES Materials and methods: Column chromatography was carried out on SiO2 (40-63 mesh). LCMS data were obtained using a Waters Symmetry 3.5μ Ci8 column (2.1 x 30.0mm, flow rate 0.8mL/min) eluting with solvent A (5% MeCN in H2O) and solvent B (MeCN solution containing 0.1% HCO2H) over 6min and UV detection at 220nm. Gradient information: 0.0-1.2min: 100% A; 1.2- 3.8min: Ramp up to 10% A-90% B; 3.8-4.4min: Hold at 10% A-90% B; 4.4-5.5min: Ramp up to 100% B; 5.5-6.0min: Return to 100% A. The mass spectra were obtained employing an electrospray ionisation source in the positive (ES+) ion mode. Prep HPLC purification was carried out using a Lunar 10 μ ODS2 (250 x 21.2mm; flow rate 20mL/min) eluting with solvent A (0.05% TFA, 10% MeCN, 90% water) and solvent B (0.05% TFA, 90% MeCN, 10% water) and UV detection at 215 nm. Gradient information: 0.0-0.2 min: 90% A, 10% B; 0.2-10.0 min: Ramp up to 10% A, 90% B; 10.0-15.0 min: 10% A, 90% B; 15.0-16.0 min: Return to 90% A, 10% B.

Preparation 1: 5-Fluorothiazol-2-ylamine hydrochloride (Method T)

H2N XT' HCI

NEt3 (63.4mL, 455mmol) was added to a stirred suspension of 5-bromothiazol-2- ylamine hydrobromide (102.7g, 379mmol) in CH2Cl2 (1.5L). After Ih, TFAA (64.2mL, 455mmol) was added dropwise at O0C over 15min. The mixture was allowed to warm to 200C over Ih, before being stirred for an additional 2h. H2O (60OmL) was added and the resulting precipitate was collected. The aqueous layer of the filtrate was separated and extracted with CHCl3 (3 x 30OmL). The combined organic extracts were washed with brine, dried (Na2SO4), filtered and concentrated. The collected precipitate and residual solid were combined and triturated with EtOAc-Zz-C6Hi4 to give N-(5-bromothiazol-2-yl)-2,2,2- trifluoroacetamide: 4 (CDCl3): 7.45 (IH, s), 13.05 (IH, br). ??-BuLi (253mL of a 1.58M solution in hexanes, 403mmol) was added dropwise over 50min to a stirred solution of the above amide (50.Og, 183mmol) in anhydrous THF (1.3L) at -78°C. After 1.5h, a solution of N-fluorobenzenesulphonimide (86.Og, 275mmol) in anhydrous THF (25OmL) was added dropwise over 30min. The mixture was stirred for 3h, before being warmed up to ~30°C. H2O (30OmL) was added and the mixture was filtered through a Celite pad. The solid collected and Celite were washed with Et2O (40OmL) and H2O (40OmL). The organic layer of the filtrate was separated and extracted with water (2 x 40OmL). The combined aqueous layers were washed with Et2O (40OmL), before being acidified to pH 6.5 with 2M HCl and extracted with EtOAc (2 x 40OmL). The combined organic extracts were washed with H2O (2 x 40OmL) and brine, before being dried (MgSO4), Filtered and concentrated. Column chromatography (EtOAc-^-C6H14, 1:3 to 1:2) gave N-(5-fluorothiazol-2-yl)-2,2,2- trifluoroacetamide: SR (CDCl3): 7.13 (IH, d). AcCl (12.6mL, 175mmol) was added dropwise to a stirred solution of this amide (15.7g, 73mmol) in MeOH (30OmL) at 00C. The mixture was stirred at 200C for 30min, heated under reflux for Ih, and finally concentrated in vacuo. The residual solid was triturated with THF to give the title compound: δa (D2O): 7.00 (IH, d).

Preparation 2: 5-Fluorothiazol-2-yIamine hydrochloride (Method IT) a) 2-(Tert-butoxycarbonyIamino)-5-fluorothiazole 2-(Tert-butoxycarbonylamino)thiazole (1Og, 0.050mol) in THF (0.2L) was cooled to - 500C under argon. tBuLi solution in pentane (6OmL of a 1.7M solution, 0.102mol, 2.05eq) was added over a period of 30min and the temperature kept below -400C. The suspension thus obtained was stirred at -500C for 30min. A solution of ν-fluorobenzenesulfonimide (νFSi) was prepared (22.Og, 0.07mol in 7OmL THF, 1.4eq) and 5OmL of this solution (leq) was added over a 5min period and the temperature kept under -400C. The reaction was stirred for 20min at -500C. Then tBuLi (1OmL, 0.017mol, 0.35eq) and the νFSi solution (1OmL, 0.4eq) added. The solution thus obtained was stirred at -50°C for 45min and then added to saturated NH4Cl solution (30OmL). The organic phase was separated and the aqueous phase further washed with diethylether (10OmL). The combined organic fractions were washed with brine (2OmL) solution and dried (Na2SO4). The solvent was removed and the solid further dried to afford a brown solid. To this crude product was added trifluoroethanol (6OmL) and formic acid (0.6mL). The suspension was heated to 85°C until it gave a solution. The flask was then cooled to RT and the precipitate thus formed filtered off to afford, after drying under high vacuum, the title compound (6.4g, contains 2.3% of starting material according to HPLC at 275nm). After a second crystallisation (trifluoroethanol (22mL) and formic acid (0.22mL) for 20min at 85°C), the title compound was obtained as an off white solid (4.6g, contains 1% of starting material, 97.5% pure by HPLC). 1HNMR (CDCl3, 300 MHz) δ: 6.90 (IH, d, CHCF), 1.60 (9H, S5 BoC-H). b) 5-FluorothiazoI-2-ylamine hydrochloride 2-(Tert-butoxycarbonylamino)-5-fluorothiazole (4.6g, 21.1mmol) was dissolved in dioxane (25mL). HCl gas was bubbled through the solution for 4h, then diethyl ether (5OmL) was added to give a suspension which was filtered off. The solid was dried in high vacuum to afford the title compound (3.03g, 19.7mmol, 93% yield). 1HNMR (D2O) δ: 7.00 (IH, d); m/z = 119.0 [M + H]+. Preparation 3: Ethyl (4-cyclopropylsulfanyIphenyl)oxoacetate

AlCl3 (104.6g, 0.79mol) was suspended in CH2Cl2 (1.15L) and cooled in an ice/salt bath to O0C with stirring. Ethyl chlorooxoacetate (84.8g, 0.62mol) was then added over a period of lOmin, during which time the temperature was maintained between 0 and 20C. The mixture was then stirred for a further 30min at O0C, before the addition of cyclopropylphenylsulfide (85.Og, 0.57mol) over a period of 45min, during which time the temperature remained between 0 and 80C. The resulting mixture was allowed to warm to room temperature and stirred for a further 2h. After this time ice/water (275mL) was added, with ice bath cooling maintaining the temperature at 2O0C. The organic layer was separated and washed with water (2 x 25OmL), saturated NaHCO3 solution (2 x 25OmL) and again with water (1 x 25OmL). The organic fraction was then dried (MgSC^) filtered and the solvent removed to provide the title compound (134g, 94% yield). NMR was consistent with the above structure.

Preparation 4: Ethyl (4-cyclopropylsulfonylphenyl)oxoacetate

To a stirred solution of Preparation 3 (49.4g, 0.2mol) in CH2Cl2 (18OmL) was added a solution of m-chloroperoxybenzoic acid (92.Og, 0.40mol, calc as 75% strength) in CH2Cl2 (65OmL) over 45min with the temperature maintained at 15-250C. TLC (CH2Cl2:ethyl acetate 1:10) showed that starting material still remained. Further m-chloroperoxybenzoic acid (3.4g) in CH2Cl2 was added and the reaction stirred for 30min. A second TLC still showed the presence of some starting material, and additional m-chloroperoxybenzoic acid (3.4g) was added and the reaction stirred for a further 2h. TLC showed a small amount of starting material so a final quantity of m-chloroperoxybenzoic acid (1.Og) was added and the reaction continued for Ih. Sodium carbonate solution (2M, 500ml) was then added and the aqueous layer was separated, the pH raised to 9-10 and reextracted with CH2Cl2. The organic extracts were combined, washed with water (2 x 400ml), dried (MgSC^), filtered and the solvent removed under vacuum (54.1g, 96% yield). NMR was consistent with the above structure. Preparation 5: (Tetrahydropyran-4-yl)methanoI

To a suspension of LiAItL1 (56g, 1.47mol) in diethyl ether (2L) under argon was added methyl tetrahydro-2H-pyran-4-carboxylate (27Og, 1.88mol) in diethyl ether (ca. 20OmL) under reflux over a period of 1.75h. After addition was complete reflux was continued for a further Ih. TLC (diethyl ether) indicated a small amount of ester remained, so further LiAlH4 (1Og, 0.26mol) was added and reflux continued for Ih. Water (66mL) was added, then 15% NaOH solution (66mL), followed by further water (198mL). The solid was filtered and dried to give the crude product, which was redissolved in DCM (800 ml), dried (MgS04),filtered and the solvent removed to afford the title compound (207 g, 94% yield). NMR was consistent with the above structure.

Preparation 6: Methanesulfonicacid (tetrahydropyran-4-yl)methyl ester

To a mixture of Preparation 5 (216.5g, 1.87mol) and triethylamine (299mL) in DCM (1.3L) at <10°C was added under argon a solution of methanesulfonyl chloride (236g, 16OmL) in DCM (20OmL) over 2h 50min, maintaining the temperature at 5-1O0C throughout. Subsequent washing with water (IL), IM HCl (50OmL), 5% NaHCO3 (30OmL), water (30OmL), drying (MgSO4) and then removal of the solvent afforded the title compound (328g, 90% yield). NMR was consistent with the above structure.

Preparation 7: 4-Iodomethyltetrahydropyran

A mixture of Preparation 6 (328g, 1.69mol) and sodium iodide (507g, 3.4mol) in acetone (3.3L) was refluxed for 4h. TLC (diethyl ether) showed significant mesylate remaining so further sodium iodide (127g, 0.65mol) was added and reflux continued for 16h. The mixture was cooled and filtered. The resulting cake was washed with acetone, dried, and then partitioned between diethyl ether (80OmL) and water (80OmL). The aqueous phase was re-extracted with diethyl ether (20OmL), the ether extracts combined and washed with 10% sodium thiosulphate solution (30OmL) which decolourised the extract. Final washing with water (30OmL), drying (MgSC^) and then removal of the solvent provided the title compound (365g, 92% yield). NMR was consistent with the above structure.

Preparation 8: Triphenyl(tetrahydropyran4-ylmethyl)phosphonium iodide

A mixture of Preparation 7 (35Og, 1.55M) and triphenylphosphine (406g, 1.55M) in acetonitrile (1.6L) was heated under reflux. After 27h the mixture was cooled and filtered, washed with diethyl ether and dried in air to provide a white solid (504g). Filtrate and washings were returned to reflux and concentrated to 75OmL, reflux was maintained for 16h before cooling and dilution with diethyl ether (ca 1.2L). A precipitate formed which was stirred for 30min before being filtered, washed with diethyl ether (2 x 30OmL) and dried in air to yield a further crop (10Og). Overall yield of the title compound (604 g, 80%). RT = 2.7min; m/z (ES+) = 361.2.

Preparation 9: (£)-2-(4-CyclopropanesulfonylphenyI)-3-(tetrahydropyran-4-y l)acryIic acid

To a suspension of Preparation 8 (2.49kg, 5.10mol) in diy THF (5L) maintained between -5 and O0C was added a solution of lithium hexamethyldisilazide (1.05M, 4.39kg, 5.18mol) over 30min. The resulting mixture was then warmed to 150C and stirred for 2h before recooliπg to between 0 and 50C. A solution of Preparation 4 (1.25kg, 4.43mol) in THF (2.5L) was then added over Ih, during which time the temperature was maintained between 0 and 50C, before a period of 16h at between 20 and 250C. Subsequently, brine (17% w/w, 3.8L) was added and the phases separated with the aid of additional brine (1.3L). The aqueous phase was reextracted with methyl t-butyl ether (2 x 2.5L) and the combined organic extracts washed with brine (2 x 3.8L). The solvents were removed under vacuum at between 30 and 4O0C. The residue was dissolved in methanol (15L) and aqueous sodium hydroxide (2M, 4.34L) added before heating at 65-670C for 4h. The mixture was cooled and the solvents removed under vacuum at between 35 and 4O0C until water started to distil. The residue was diluted with water (15L). The solid phosphine oxide was filtered off, washed with water (2.5L) and the filtrate separated. The aqueous phase was washed with methyl t- butyl ether (5L and 3.5L), before acidification with hydrochloric acid solution (5M, 1.9L) in the presence of methyl t-butyl ether (10L). The organic phase was separated and the aqueous phase reextracted with methyl t-butyl ether (5L). The combined organic extracts were washed with saturated brine (2 x IL) and the solvent removed under vacuum. Methanol (2L) was added and then removed under vacuum, this step was then repeated. The residue was brought to a total weight of 4.0kg by addition of methanol and stirred at ambient temperature to crystallise the product. Filtration of the solid and washing with chilled (ca O0C) methanol (50OmL) gave, after vacuum drying at 4O0C, the title compound (654g, 41% yield after correction for residual solvent). NMR was consistent with the above structure.

Example 1: Preparation of (2i?)-2-(4-cyclopropanesulfonyIphenyl)-3- (tetrahydropyran-4-yl)propionic acid (£)-2-(4-Cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-y l)acrylic acid (Preparation 9, HOg, 0.327mol) was dissolved in MeOH/Toluene 5:1 (1.4L). In a 4.OmL Schlenk flask was placed [Rh(nbd)2] (BF4) (30.5mg, O.Oδmmol) and All-MOD-Mandyphos (90.4mg, 0.08mmol), dissolved in MeOH (1OmL) and stirred for Ih at RT. This catalyst solution was then added to the (£)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4- yl)acrylic acid solution and transferred to a 2.5L autoclave. The autoclave was pressurized to 50 bar and heated to 3O0C. After 18h the pressure was released and the solution transferred to a 3L flask. Active charcoal (3g) was added to the reaction mixture, stirred for Ih and the charcoal removed by filtration. The solution was further filtered over Hyflo and a Zeta-Bond filter. The solution thus obtained was concentrated under partial pressure and the solid obtained further dried under high vacuum to give a solid (105g). The solid was placed in a 1.5L flask equipped with a mechanical stirrer, a thermometer and a dropping funnel. Isobutylacetate (54OmL) was added at RT and the suspension heated at 1100C until a clear solution was observed. Heptane (6OmL) was added slowly at HO0C, the oil bath was then removed and the solution allowed to cool slowly. The reaction was stirred for a further 16h, the title compound filtered off and dried under high vacuum (77.2g, 70% yield, 99% ee). 1H NMR (CDCl3, 300.13 MHz) δ: 7.85 (2H, Aiyl H, d, JHH = 6.6 Hz), 7.50 (2H, Aryl H, d, JHH = 6.6 Hz), 3.95 (br d, 2H), 3.80 (t, IH, CHCH2, JHH = 7.8 Hz), 3.35 (m, 2H), 2.45 (m, IH), 2.10 (m, IH), 1.75 (m, IH), 1.60 (m, 2H), 1.50-1.20 (m, 5H), 1.05 (m, 2H).

Example 2 : Preparation of (2ϋ)-2-(4-cycIopropanesuIfonylphenyl)-iV-(5- fluorothiazoI-2-yl)-3-(tetrahydropyran-4-yl)propionamide A mixture Of CH2Cl2 (1.35L) and DMF (35.9mL, 0.465mol, 1.5eq) was cooled to - 200C and oxalylchloride (39.4mL) slowly added (0.465mol, 1.5eq). After stirring for 45min (2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran-4-y l)propionic acid (Example 1, 105.Og, 0.3 lOmol, leq) was added. The reaction was stirred at -200C for Ih. Collidine (185mL, 1.395mol, 4.5eq) was then slowly added. The reaction mixture was stirred for 15min and then 5-fluorothiazol-2-ylamine hydrochloride (Preparation 1, 52.7g, 0.341mol, l.leq) was added at -150C. The resulting suspension was kept at -15°C for 2h after which the ice bath was removed and the reaction slowly warmed to RT over a period of 2h. The mixture was evaporated to dryness to afford a semi-solid to which was added portionwise 4N HCl solution (1.5mL). The product was extracted with ethylacetate (3L) and the organic fraction further washed with water (IL) and saturated NaHCO3 solution (IL). The solvent was removed under partial vacuum to give the title compound (135g). Characterising data was consistent with the formation of the title compound.

Example 3: Preparation of (2jR)-2-(4-cydopropanesulfonylphenyl)-iV-pyrazin-2-yl-3- (tetrahydropyran-4-yl)propionamide In a 1OL reaction vessel purged with N2 were placed dichloromethane (2L) and N5N- dimethylformamide (54.7mL, 0.709mol). The solution was cooled to -1O0C and oxalylchloride (60.OmL, 0.709mol) slowly added over 15min resulting into strong gas evolution. The white suspension which formed was stirred until no more gas evolved then cooled to -200C. A suspension of (2R)-2-(4-cyclopropanesulfonylphenyl)-3-(tetrahydropyran- 4-yl)propionic acid (Example 1, 20Og, 0.590mol) in dichloromethane (IL) was added over Ih. The yellow solution was stirred for a further 0.5h, then cooled to -45°C and a solution of pyridine (51.OmL, 0.590mol) in dichloromethane (0.25L) added over 20min. While the temperature was kept under -45°C, a suspension of 2-aminopyrazine (112.4g, l.lSOmol) in THF (LlL) and a solution of pyridine (154mL, 1.770mol) in dichloromethane (0.9L) were added in parallel over 1.25h. The cooling bath was removed and the orange suspension was stirred for a further 16h. The solution was concentrated under vacuum by means of a rotavap (250mbar, 500C) and 3 x 800 mL portion of ethyl acetate were added and further distilled off. To the brown oil were added ethyl acetate (2L) and aqueous HCl (2M, 2L). The phases were separated and the organic phase further washed with aqueous HCl (2M, 2 x IL). The aqueous phase were collected and washed with ethyl acetate (2L). The organic phases were collected and washed with water (2L) and a saturated solution OfNaHCO3 (2 x IL). The HPLC analysis of the basic aqueous phase showed it contained some product and therefore was extracted with ethyl acetate (2L). The organic fractions were collected and washed with water (IL) and brine (IL). The organic phase was dried over Na2SC^ and the suspension filtered off over a paper filter. The solvent was removed by means of a rotavap (125 mbar, 500C) and ethanol was added portionwise (3 x 0.5L) to ensure complete removal of the ethyl acetate for the next step. A brown oil was isolated (248 g) which according to HPLC and 1H NMR analyses was 96.5% pure and contained 16 % of ethanol (%ee > 98.0%). Corrected yield: 207.3g (84%). Characterising data was consistent with the formation of the title compound.

Example 4: Preparation of (2J?)-2-(4-cycIobutanesulfonyIphenyl)-3- (tetrahydropyran-4-yl)propionic acid In a 30OmL autoclave were placed (£)-2-(4-cyclobutanesulfonylphenyl)-3- (tetrahydropyran-4-yl)acrylic acid (5.4g, 15.5mmol, prepared by a process analogous to Preparation 9 and that described in PCT/US04/03968), and of MeOH/Toluene 5:1 solution (17OmL). The autoclave was closed and evacuated by means of 10 cycles of vacuum /N2 (10 bar). In a separate Schlenk flask are placed and degassed of MeOH/Toluene 5: 1 solution (1OmL). Then the ligand (R)-(S)-MOD-Mandyphos (34.75mg, O.033mmol) and [Rh(nbd)2](BF4) (11.6mg, 0.03 lmmol) were added to the Schlenk flask and the apparatus degassed by means of 5 cycles of vacuum / N2. The thus prepared catalyst solution was transferred in the autoclave and 50 bar of H2 pressure were applied. The reaction was stirred over night. The pressure was released. The solution was evaporated to dryness by means of a rotavap to afford a beige solid (4.5g, 88%ee (R)). In a 25OmL reaction vessel were added the crude product and isobutylacetate (8OmL). The suspension was heated at 11O0C until a clear solution was observed. Then heptane (8mL) was added at 1100C. The oil bath was then removed and the solution cooled down slowly. After standing over night, the precipitate was filtered off and the light beige crystalline solid dried under vacuum (500C, 200 mbar). After an IPC (HPLC: 93%ee) the crude product was dissolved again in isobutylacetate (8OmL) at 1100C. Once the solution was clear, heptane (8mL) was added. The oil bath was then removed and the solution cooled down slowly. After standing over night, the precipitate was filtered off and the light beige crystalline solid dried under vacuum (5O0C, 200 mbar). This afforded the title compound (3.8 g). Characterising data was consistent with the formation of the title compound. Example 5: Preparation of (2λ)-2-(4-cycIobutanesulfonylphenyl)-iV-(l-methyI--LH- pyrazol-3-yI)-3-(tetrahydropyran-4-yI)propionamide In a 100 inL three neck round bottom flask were placed CH2Cl2 (4OmL) and (2R)-2- (4-cyclobutanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propio nic acid (Example 4, 1.2g, 3.4 mmol). The solution was cooled to -200C before DMF (0.273g, 3.74 mmol, 1.1 eq.) and oxalylchloride (0.32g, 3.74 mmol, 1.1 eq) were added. The reaction was further stirred at - 20°C for Ih to afford a slightly yellow solution. l-Methyl-lH-3-aminopyrazole (0.99g, 10.2mmol, 3eq) was added at -200C, then 0.55 g pyridine (0.55g, 6.8mmol, 2eq) was added over the course of lOmin. After stirring at -200C for 45min an IPC was taken. No more acid chloride was present. The reaction solution was warmed up to room temperature before taking up in ethylacetate (10OmL) and washing twice with HCl (IM, 10OmL) followed by washing twice with saturated NaHCO3. The organic phase was dried over Na2SO4 before the solvent was removed. Crude product 1.2 g (82%); HPLC purity: >98%; Enantioselectivity: 98%. Characterising data was consistent with the formation of the title compound.