Title:
ENGINEERED ANTI-TROP2 ANTIBODY AND ANTIBODY-DRUG CONJUGATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/152308
Kind Code:
A1
Abstract:
Provided herein is an engineered dimeric antibody comprising in each monomer a Fab domain specifically binding to a Trop2 antigen operably linked to an engineered hinge region, wherein the engineered hinge region is composed of a portion of truncated IgG1 hinge region and a portion of truncated IgG4 hinge region such that the engineered dimeric antibody comprises at least two inter-chain disulfide bonds in its hinge domain. Also provided is an antibody-drug conjugate comprising the engineered antibody conjugated to one or more drug molecules through a linker, a method of its preparation, a composition comprising same and its use in treatment of cancers.
Inventors:
JIN MINGZHI (CN)
ZHOU QING (CN)
WANG JIA (CN)
YIN LI (CN)
WANG JUN (CN)
ZHOU QING (CN)
WANG JIA (CN)
YIN LI (CN)
WANG JUN (CN)
Application Number:
PCT/CN2022/072469
Publication Date:
July 21, 2022
Filing Date:
January 18, 2022
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
A61K39/395; C07K16/30; A61K47/68; A61P35/00; C07K19/00; C12N5/10; C12N15/13; C12N15/85
Foreign References:
| CN107446050A | 2017-12-08 | |||
| CN111228510A | 2020-06-05 | |||
| CN111087471A | 2020-05-01 | |||
| CN111018992A | 2020-04-17 | |||
| CN105849126A | 2016-08-10 | |||
| US20150018529A1 | 2015-01-15 | |||
| US20130323236A1 | 2013-12-05 | |||
| US20170165370A1 | 2017-06-15 |
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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