Title:
ENHANCEMENT OF OLIGONUCLEOTIDE INHIBITION OF PROTEIN PRODUCTION, CELL PROLIFERATION, AND/OR MULTIPLICATION OF INFECTIOUS DISEASE PATHOGENS
Document Type and Number:
WIPO Patent Application WO1995003406
Kind Code:
A3
Abstract:
The invention features the use of a purified first targeted oligonucleotide in combination with either 1) a subtargeted oligonucleotide, 2) second targeted oligonucleotide, or 3) a non-targeted phosphorothioate oligonucleotide, to inhibit protein production of a targeted nucleic acid sequence, cell proliferation, and/or the multiplication of a foreign organism. The subtargeted oligonucleotide contains a truncated version of the targeted oligonucleotide.
Inventors:
DATTAGUPTA NANIBHUSHAN
SRIDHAR C NAGARAJA
KACIAN DANIEL L
SRIDHAR C NAGARAJA
KACIAN DANIEL L
Application Number:
PCT/US1994/008334
Publication Date:
September 14, 1995
Filing Date:
July 19, 1994
Export Citation:
Assignee:
GEN PROBE INC (US)
International Classes:
C12N15/09; A61K31/70; A61K48/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; C07H21/04; C12N5/10; C12N15/113; C12R1/92; (IPC1-7): C12N15/11; A61K31/70; A61K48/00; C12N9/00
Domestic Patent References:
| WO1993015194A1 | 1993-08-05 | |||
| WO1992014843A1 | 1992-09-03 |
Foreign References:
| EP0318245A2 | 1989-05-31 | |||
| EP0288163A2 | 1988-10-26 |
Other References:
R.B. DENMAN: "Cleavage of full length APP mRNA by mannerhead ribozymes", NUCLEIC ACIDS RESEARCH, vol. 21, no. 17, pages 4119 - 4125
L.J. MAHER III ET AL.: "Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleotide methylphosphonates in a cell-free system", NUCLEIC ACIDS RESEARCH, vol. 16, no. 8, pages 3341 - 3358
J. GOODCHILD: "Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitatot) and by 2'-O-methylation", NUCLEIC ACIDS RESEARCH, vol. 20, no. 17, pages 4607 - 4612
J.M. BURKE ET AL.: "In vitro selection and evolution of RNA...", FASEB JOURNAL, vol. 7, no. 1, pages 106 - 112
C. MAJUMDAR ET AL.: "Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide", BIOCHEMISTRY, vol. 28, pages 1340 - 1346
L.J. MAHER III ET AL.: "Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleotide methylphosphonates in a cell-free system", NUCLEIC ACIDS RESEARCH, vol. 16, no. 8, pages 3341 - 3358
J. GOODCHILD: "Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitatot) and by 2'-O-methylation", NUCLEIC ACIDS RESEARCH, vol. 20, no. 17, pages 4607 - 4612
J.M. BURKE ET AL.: "In vitro selection and evolution of RNA...", FASEB JOURNAL, vol. 7, no. 1, pages 106 - 112
C. MAJUMDAR ET AL.: "Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide", BIOCHEMISTRY, vol. 28, pages 1340 - 1346
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