Title:
EPOTHILONE ANALOGUES, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR USE AND THEIR PREPARATIONS
Document Type and Number:
WIPO Patent Application WO/2009/105969
Kind Code:
A1
Abstract:
The invention discloses novel epothilone analogues, their pharmaceutical compositions, their use and their preparations, especially discloses the compounds of the following formula, their preparations and their use for preparing therapeutical compositions used as cell inhibitors.
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Inventors:
QIU RONGGUO (CN)
Application Number:
PCT/CN2009/000218
Publication Date:
September 03, 2009
Filing Date:
March 02, 2009
Export Citation:
Assignee:
TANG LI (CN)
QIU RONGGUO (CN)
QIU RONGGUO (CN)
International Classes:
C07D313/00; A61K31/422; A61K31/427; A61P35/00; C07C53/00; C07D315/00; C07D413/06; C07D417/06; C07D417/14
Domestic Patent References:
| WO1999027890A2 | 1999-06-10 |
Foreign References:
| CN1521258A | 2004-08-18 | |||
| US6204388B1 | 2001-03-20 | |||
| CN1629283A | 2005-06-22 | |||
| CN1521258A | 2004-08-18 | |||
| US6458373B1 | 2002-10-01 |
Other References:
HOFLE, ANGEW. CHEM. INT. ED. ENGL., vol. 35, 1996, pages 1567 - 1569
GERTH, J. ANTIBIOTICS, vol. 49, no. 6, 1996, pages 560 - 563
ALTMANN, BIOCHEM. BIOPHYS. ACTA, vol. 1470, no. 3, 2000, pages 79 - 91
BOLLAG, CANCER RES., vol. 55, no. 11, pages 2325 - 2333
M. YAMAGUCHI, BULL. CHEM. SOC. JPN., vol. 52, 1979, pages 1989
A.RIVKIN, J.AM.CHEM.SOC., vol. 125, 2003, pages 2899
MENG, D., J. ORG. CHEM., vol. 61, 1996, pages 7999
TAYLAR, R.E., TETRAHEDRON LETT., vol. 38, 1997, pages 2061
NICOLAOU, K.C., ANGEW.CHEM. INT. ED. ENGL., vol. 36, 1997, pages 166
SCHINZER, D., EUR.CHEM.CHRON., vol. 1, 1996, pages 7
GRUBBS., ANGEW. CHEM. INT. ED. ENGL., vol. 34, 1995, pages 2039
SCHROCK,R.R., J. AM. CHEM. SOC., 1990, pages 112 - 3875
SKEHAN, J. NATL. CANCER INST., vol. 82, 1990, pages 1107
GIANAKAKOU, INTL. J. CANCER, vol. 75, 1998, pages 63
See also references of EP 2261221A4
GERTH, J. ANTIBIOTICS, vol. 49, no. 6, 1996, pages 560 - 563
ALTMANN, BIOCHEM. BIOPHYS. ACTA, vol. 1470, no. 3, 2000, pages 79 - 91
BOLLAG, CANCER RES., vol. 55, no. 11, pages 2325 - 2333
M. YAMAGUCHI, BULL. CHEM. SOC. JPN., vol. 52, 1979, pages 1989
A.RIVKIN, J.AM.CHEM.SOC., vol. 125, 2003, pages 2899
MENG, D., J. ORG. CHEM., vol. 61, 1996, pages 7999
TAYLAR, R.E., TETRAHEDRON LETT., vol. 38, 1997, pages 2061
NICOLAOU, K.C., ANGEW.CHEM. INT. ED. ENGL., vol. 36, 1997, pages 166
SCHINZER, D., EUR.CHEM.CHRON., vol. 1, 1996, pages 7
GRUBBS., ANGEW. CHEM. INT. ED. ENGL., vol. 34, 1995, pages 2039
SCHROCK,R.R., J. AM. CHEM. SOC., 1990, pages 112 - 3875
SKEHAN, J. NATL. CANCER INST., vol. 82, 1990, pages 1107
GIANAKAKOU, INTL. J. CANCER, vol. 75, 1998, pages 63
See also references of EP 2261221A4
Attorney, Agent or Firm:
LUNG TIN INTERNATIONAL INTELLECTUAL PROPERTY AGENT LTD. (Tower B Grand Place,N0. 5, Huizhong Road,Chaoyang District, Beijing 1, CN)
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