ERYTHROMYCIN DERIVATIVE HAVING NOVEL CRYSTAL STRUCTURES AND PROCESSES FOR THEIR PRODUCTION

Title:

ERYTHROMYCIN DERIVATIVE HAVING NOVEL CRYSTAL STRUCTURES AND PROCESSES FOR THEIR PRODUCTION

Document Type and Number:

WIPO Patent Application WO/2002/030943

Kind Code:

A1

Abstract:

Form E crystals of N-demethyl-N isopropyl-12-methoxy-11 -oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fumarate produced by treating form E crystals of N-demethyl-N-isopropyl -12-methoxy-11-oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fumarate exhibiting intense diffraction peaks at diffraction angles (2$g(u)) of 5.6° and 10.4° in powder X-ray diffractometry and form C crystals of the same in a mixed solvent consisting of ethyl acetate and water at 20 to 40°C; and form D crystals thereof obtained through the form E crystals. The crystals little contain residual solvents and are suitable for pharmaceutical preparations.

Inventors:

HIRAIDE AKIRA (JP)
KOYAMA KAICHIRO (JP)
SHIMIZU HITOSHI (JP)
TSUZAKI KANAME (JP)

Application Number:

PCT/JP2001/008990

Publication Date:

April 18, 2002

Filing Date:

October 12, 2001

Export Citation:

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)
HIRAIDE AKIRA (JP)
KOYAMA KAICHIRO (JP)
SHIMIZU HITOSHI (JP)
TSUZAKI KANAME (JP)

International Classes:

A61K31/351; A61K31/7048; A61P1/00; C07H17/08; (IPC1-7): A61K31/7048; A61P1/00

Foreign References:

EP0846697A1	1998-06-10
EP0643068A1	1995-03-15

Other References: