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Title:
ERYTHROMYCIN DERIVATIVES AND MEDICINES CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2002/026753
Kind Code:
A1
Abstract:
Erythromycin derivatives of the following general formula or their salts, which exhibit excellent antimicrobial activities against atypical acid-fast microorganisms and are useful as antimicrobial agents, wherein R?1¿ and R?2¿ are each hydrogen, alkyl, a homo- or hetero-cyclic group, alkyl substituted with a homo- or hetero-cycle, or the like, or R?1¿ and R?2¿ may be united to form a homo- or hetero-cycle; R?3¿ is hydrogen or methyl; R?4¿ is hydroxyl or the like; R?5¿ is hydrogen, hydroxyl, or the like; R?6¿ and R?7¿ are each hydrogen, alkyl, or the like; X is NH or N-O-R?8¿; Y is O-C(=O)-R?9¿, a cladinose derivative, or the like; Z is oxygen or sulfur; and R?8¿ and R?9¿ are each alkyl, a homo- or hetero-cyclic group, alkyl substituted with a homo- or hetero-cycle, or the like.

Inventors:
KATO HIDEO (JP)
YOSHIDA TOSHIHIKO (JP)
NISHIMOTO AKEMI (JP)
OHMOTO SHINOBU (JP)
Application Number:
PCT/JP2001/008388
Publication Date:
April 04, 2002
Filing Date:
September 26, 2001
Export Citation:
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Assignee:
HOKURIKU PHARMACEUTICAL (JP)
KATO HIDEO (JP)
YOSHIDA TOSHIHIKO (JP)
NISHIMOTO AKEMI (JP)
OHMOTO SHINOBU (JP)
International Classes:
A61K31/7042; A61K31/7048; A61P31/04; A61P31/06; C07H17/08; (IPC1-7): C07H17/08; A61K31/7048; A61P31/04
Domestic Patent References:
WO1999029709A11999-06-17
WO1998023628A11998-06-04
WO1995056801A1
WO2000061593A12000-10-19
Foreign References:
JP2000351793A2000-12-19
Other References:
BIEDRZYCKI MAREK ET AL.: "Erythromycin derivatives. Part VI. Carbamates of cyclic 11,12-carbonate of erythromycin A", POL. J. CHEMICAL, vol. 52, no. 2, 1978, pages 315 - 319, XP002085921
Attorney, Agent or Firm:
Imamura, Masazumi (Kyobashi-Nisshoku Bldg. 8-, Kyobashi 1-chome Chuo-ku Tokyo, JP)
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