Title:
ERYTHROMYCIN A DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/021868
Kind Code:
A1
Abstract:
Erythromycin A derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof: wherein n represents an integer of 1 to 8; R?1¿ represents hydrogen or C¿1?-C¿6? alkyl; R?2¿ represents pyridylmethyl, quinolylmethyl, pyridylsulfonyl or quinolylsulfonyl; R?3¿ represents hydrogen, C¿1?-C¿6? alkyl or cinnamyl; and R?4¿ represents cladinosyloxy or a group represented by general formula (II): wherein m represents 0 or 1 and R?5¿ represents phenyl, pyridyl, quinolyl, phenyl having one to three substituents selected among C¿1?-C¿6? alkyl, nitro, C¿1?-C¿3? alkoxy and halogeno, or pyridyl or quinolyl each having one or two substituents selected among C¿1?-C¿6? alkyl, nitro, C¿1?-C¿3? alkoxy and halogeno.
Inventors:
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
SUGIMOTO TOMOHIRO (JP)
TANIKAWA TETSUYA (JP)
ISHII TAKAAKI (JP)
MATSUURA AKIKI (JP)
KASHIMURA MASATO (JP)
SUGIMOTO TOMOHIRO (JP)
TANIKAWA TETSUYA (JP)
ISHII TAKAAKI (JP)
MATSUURA AKIKI (JP)
Application Number:
PCT/JP1998/004780
Publication Date:
May 06, 1999
Filing Date:
October 22, 1998
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
SUGIMOTO TOMOHIRO (JP)
TANIKAWA TETSUYA (JP)
ISHII TAKAAKI (JP)
MATSURA AKIKI (JP)
ASAKA TOSHIFUMI (JP)
KASHIMURA MASATO (JP)
SUGIMOTO TOMOHIRO (JP)
TANIKAWA TETSUYA (JP)
ISHII TAKAAKI (JP)
MATSURA AKIKI (JP)
International Classes:
C07H17/08; (IPC1-7): C07H17/08
Other References:
HUNT E., ET AL.: "9,11-CYCLIC ACETAL DERIVATIVES OF (9S)-9-DIHYDROERYTHROMYCIN A.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 42., no. 02., 1 January 1989 (1989-01-01), GB, pages 293 - 298., XP002915959, ISSN: 0021-8820
Attorney, Agent or Firm:
Kitagawa, Tomizo (Ltd. Patent Division 24-1, Takata 3-chome Toshima-ku Tokyo, JP)
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