Title:
EXTERNAL PREPARATION CONTAINING RAPAMYCIN
Document Type and Number:
WIPO Patent Application WO/2021/149827
Kind Code:
A1
Abstract:
[Problem] To provide an external preparation that contains rapamycin, has high stability and is efficacious in treating skin diseases. [Solution] An external preparation that contains (a) rapamycin, (b) at least one member selected from the group consisting of ethylene glycol salicylate, diethyl sebacate and triacetin, and (c) propylene glycol and/or polyethylene glycol, an external preparation that further contains an antioxidant, and an external preparation that further contains a solution of an antioxidant in a lipophilic solvent.
Inventors:
YASUZAWA TORU (JP)
IGAKI MATSUO (JP)
MATSUMOTO TAKUMA (JP)
HIMI SATOSHI (JP)
IGAKI MATSUO (JP)
MATSUMOTO TAKUMA (JP)
HIMI SATOSHI (JP)
Application Number:
PCT/JP2021/002352
Publication Date:
July 29, 2021
Filing Date:
January 23, 2021
Export Citation:
Assignee:
NOBELPHARMA CO LTD (JP)
International Classes:
A61K31/436; A61K9/06; A61K47/10; A61K47/14; A61P17/00; A61P37/06
Domestic Patent References:
| WO1999055332A1 | 1999-11-04 | |||
| WO2018129364A1 | 2018-07-12 | |||
| WO2004069261A1 | 2004-08-19 | |||
| WO2018031789A1 | 2018-02-15 | |||
| WO2018129364A1 | 2018-07-12 |
Foreign References:
| JPH0797312A | 1995-04-11 | |||
| JPH08259423A | 1996-10-08 | |||
| JP2001233772A | 2001-08-28 | |||
| JP2019527711A | 2019-10-03 | |||
| JPH06128148A | 1994-05-10 |
Other References:
BUECH, G. ET AL.: "Formulation of eye drops and corneal permeation studies", JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, vol. 23, no. 3, 2007, pages 292 - 303, XP002608839, DOI: 10.1089/JOP.2006.130
SOBHANI, H. ET AL.: "Formulation development and toxicity assessment of triacetin mediated nanoemulsions as novel delivery systems for rapamycin", IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 14, 2015, pages 3 - 21, XP055842498
See also references of EP 4094761A4
SOBHANI, H. ET AL.: "Formulation development and toxicity assessment of triacetin mediated nanoemulsions as novel delivery systems for rapamycin", IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 14, 2015, pages 3 - 21, XP055842498
See also references of EP 4094761A4
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