Title:
EYEDROP COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2020/057606
Kind Code:
A1
Abstract:
The present disclosure provides a veterinary artificial tear composition comprising a first polymer and a second polymer, wherein said first polymer and said second polymer are cross-linkable to form a hydrogel, wherein: said first polymer is a hyaluronic acid modified with vinylsulfone, said hyaluronic acid has a molecular weight of 2.6 MDa, said first polymer has a degree of modification of 35%, and said first polymer is present in said composition with a concentration of 0.32 mg/ml; said second polymer is a hyaluronic acid modified with thiol, said hyaluronic acid has a molecular weight of 2.6 MDa, said second polymer has a degree of modification of 35%, and said second polymer is present in said composition with a concentration of 0.32 mg/ml; and a molar ratio between said first polymer and said second polymer in said composition is 1:1. The present disclosure also provides methods for using the same.
Inventors:
CHAU YING (CN)
YU YU (CN)
YU YU (CN)
Application Number:
PCT/CN2019/106689
Publication Date:
March 26, 2020
Filing Date:
September 19, 2019
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
A61K9/08; A61K47/36; A61P27/04; C08B37/00
Domestic Patent References:
| WO2014169708A1 | 2014-10-23 | |||
| WO2013078770A1 | 2013-06-06 |
Foreign References:
| US20150250815A1 | 2015-09-10 | |||
| CN100366296C | 2008-02-06 | |||
| CN102178692A | 2011-09-14 | |||
| CN101107270A | 2008-01-16 |
Other References:
YU YU ET AL.: "Injectable Chemically Crosslinked Hydrogel for the Controlled Release of Bevacizumab in Vitreous: A 6-Month In Vivo Study", TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, vol. 4, no. 2, 10 March 2015 (2015-03-10), pages 1 - 11, XP002791841
YU YU ET AL.: "Formulation of In Situ Chemically Cross-Linked Hydrogel Depots for Protein Release: From the Blob Model Perspective", BIOMACROMOLECULES, vol. 16, no. 1, 14 October 2014 (2014-10-14), pages 56 - 65, XP055693496
YU YU ET AL.: "Formulation of In Situ Chemically Cross-Linked Hydrogel Depots for Protein Release: From the Blob Model Perspective", BIOMACROMOLECULES, vol. 16, no. 1, 14 October 2014 (2014-10-14), pages 56 - 65, XP055693496
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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