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Patent Searching and Data


Title:
FC VARIANT HAVING ALTERED EFFECTOR FUNCTION AND FUSION PROTEIN THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/063313
Kind Code:
A1
Abstract:
Disclosed are an Fc variant that has an altered effector function and a fusion protein thereof. An Fc region of the Fc variant comprises one or more amino acid changes, and has an altered effector function; further, disclosed are a fusion protein comprising the Fc variant that has an altered effector function, a method for preparing the Fc variant or the fusion protein, a nucleic acid encoding the Fc variant or the fusion protein, an expression vector comprising the nucleic acid, a host cell comprising the Fc variant, the fusion protein, the nucleic acid or the expression vector, a pharmaceutical composition comprising the Fc variant or the fusion protein, and the use of the Fc variant or the fusion protein.

Inventors:
LU LISHENG (CN)
HUO YONGTING (CN)
LIU YUNPENG (CN)
LI YANMIN (CN)
HAN ZHE (CN)
OU YINGYE (CN)
LU DI (CN)
TU JINGJING (CN)
Application Number:
PCT/CN2020/118409
Publication Date:
April 08, 2021
Filing Date:
September 28, 2020
Export Citation:
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Assignee:
SHENZHEN FEIPENG BIOLOGICAL PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K14/47; A61K38/20; A61P35/00; C07K19/00; C12N15/10
Foreign References:
CN108948207A2018-12-07
CN108948207A2018-12-07
Other References:
KEVIN O. SAUNDERS, ET AL.: "Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life", FRONTIERS IN IMMUNOLOGY, vol. 10, 7 June 2019 (2019-06-07), XP055654839, DOI: 10.3389/fimmu.2019.01296
KEVIN O. SAUNDERS, ET AL.: "Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life", FRONTIERS IN IMMUNOLOGY, vol. 10, 7 June 2019 (2019-06-07), XP055654839, DOI: 10.3389/fimmu.2019.01296
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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