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Title:
FERRITIN ENCLOSING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2021/045210
Kind Code:
A1
Abstract:
The present invention provides a peptide delivery means capable of avoiding disruption of a cell membrane, immunogenicity, and toxicity. More specifically, the present invention provides the following (1) to (3). (1) A ferritin enclosing a peptide that comprises 3 to 19 amino acid residues and satisfies the following conditions: a) -10.2 ≤ X ≤ 5.9 and 445 ≤ Y ≤ 2524 (where X represents the charge of the peptide at pH 9 and Y represents the chemical formula weight of the peptide). (2) A peptide intracellular delivery agent containing the ferritin enclosing the peptide. (3) A method for producing the ferritin enclosing the peptide.

Inventors:
INOUE IPPEI (JP)
ITO KENICHIRO (JP)
TOKUYAMA MAYUMI (JP)
Application Number:
PCT/JP2020/033658
Publication Date:
March 11, 2021
Filing Date:
September 04, 2020
Export Citation:
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Assignee:
AJINOMOTO KK (JP)
International Classes:
A61P43/00; A61K38/06; A61K38/07; A61K38/08; A61K38/10; A61K47/42; C07K1/02; C07K7/04; C12N15/12
Domestic Patent References:
WO2019163871A12019-08-29
WO2020090708A12020-05-07
WO2006126595A12006-11-30
Foreign References:
CN106110333A2016-11-16
US4515736A1985-05-07
US20160060307A12016-03-03
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Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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