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Patent Searching and Data


Title:
FLAGELLIN FUSION PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/218829
Kind Code:
A1
Abstract:
The present invention relates to a flagellin fusion protein and a use thereof and, more specifically, to a fusion protein comprising: flagellin, a fragment thereof, or a variant thereof; and an immunoglobulin Fc region, and a use in which a toll-like receptor 5 (TLR5) stimulating activity thereof is used. The fusion protein provided by the present invention has remarkably excellent toll-like receptor 5 (TLR5) pathway activation ability compared to wild-type flagellin, a fragment thereof, or a variant thereof, and therefore can be greatly utilized to develop a therapeutic agent and/or a vaccine adjuvant for a disease that can be prevented, improved, or treated through activation of the TLR5 pathway.

Inventors:
CHO KYUNG A (KR)
LIM JAE SUNG (KR)
Application Number:
KR2020/005327
Publication Date:
October 29, 2020
Filing Date:
April 22, 2020
Export Citation:
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Assignee:
UNIV NAT CHONNAM IND FOUND (KR)
International Classes:
C07K14/195; A61K39/39; A61K47/68; A61P1/00; A61P7/00; A61P17/14; A61P19/08; A61P19/10; A61P27/12; A61P43/00
Foreign References:
KR20080074556A2008-08-13
KR101287905B12013-07-23
Other References:
CZAJKOWSKY, D. M. ET AL.: "Fc-fusion proteins: new developments and future perspectives", EMBO MOLECULAR MEDICINE, vol. 4, 2012, pages 1015 - 1028, XP055542855, DOI: 10.1002/emmm.201201379
DATABASE Protein 26 September 2017 (2017-09-26), "flagellin, partial [Bacillus subtilis subsp. spizizenii str. W23]", XP055758462, retrieved from NCBI Database accession no. BAB58979.1
DATABASE Protein 24 July 2016 (2016-07-24), "immunoglobulin heavy chain, constant region, partial [Homo sapiens]", XP055758464, retrieved from NCBI Database accession no. CAA04843.1
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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