Title:
FLAVONE GLYCOSIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/041195
Kind Code:
A1
Abstract:
Disclosed is a class of flavone glycoside derivatives, compounds of structural general formula (I) described below or pharmaceutically acceptable salts or hydrates thereof, comprising racemates, optical isomers and epimers thereof. Also disclosed are a method for preparing the flavone glycoside derivatives and a use thereof in preparing drugs for treating diabetes. The flavone glycoside derivatives of the present invention are used to prepare drugs for treating diabetes, and have a relatively good inhibition effect on alpha-glucosidase, thereby slow down the decomposition rate from starches to glucose and the intestinal absorption of glucose, so lower postprandial hyperglycemia, improve the activity of such compounds for treating diabetes, and have less toxicity. Their physicochemical properties are more suitable for pharmaceutical preparations for treating diabetes, thus can be used for preparing drugs for treating diabetes which have better efficacy and higher safety. In their preparation method, the steps are simple, raw materials are readily available, the product yield is high and the purity is good. The flavone glycoside derivative can be prepared into various pharmaceutical preparations for treating diabetes.
Inventors:
XU BIXUE (CN)
LIANG GUANGYI (CN)
HU ZHANXING (CN)
XIA WEN (CN)
JIANG WEI (CN)
YUAN JIE (CN)
CHEN HONGJU (CN)
ZHANG LIMEI (CN)
JIANG KUN (CN)
SUN XIAOJUN (CN)
LI XING (CN)
AN QIAO (CN)
LIANG GUANGYI (CN)
HU ZHANXING (CN)
XIA WEN (CN)
JIANG WEI (CN)
YUAN JIE (CN)
CHEN HONGJU (CN)
ZHANG LIMEI (CN)
JIANG KUN (CN)
SUN XIAOJUN (CN)
LI XING (CN)
AN QIAO (CN)
Application Number:
PCT/CN2014/086933
Publication Date:
March 24, 2016
Filing Date:
September 19, 2014
Export Citation:
Assignee:
GUIZHOU BAILING GROUP PARMACEUTIAL CO LTD (CN)
International Classes:
A61K31/7048; A61P3/10; C07H1/00; C07H17/07
Foreign References:
| CN1442146A | 2003-09-17 | |||
| CN102827221A | 2012-12-19 |
Other References:
HOSSAM, M.A. ET AL.: "Antidiabetic Activity of Phenolic Compounds from Pecan Bark in Streptozotocin-Induced Diabetic Rats.", PHYTOCHEMISTRY LETTERS., vol. 4, no. 3, 22 July 2011 (2011-07-22), pages 337 - 341, XP028299113, DOI: doi:10.1016/j.phytol.2011.07.004
WANG, YIHAI ET AL.: "Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus Alba L.) Polyphenol Enhanced Extract.", PLOS ONE., vol. 8, no. 7, 30 July 2013 (2013-07-30), pages e71144
SEPULVEDA-BOZA, S. ET AL.: "Flavonoids from the Twigs of Eucryphia Glutinosa.", PHYTOCHEMISTRY, vol. 32, no. 5, 31 December 1993 (1993-12-31), pages 1301 - 3
MARZOUK, M.S. ET AL.: "Polyphenolic Metabolites of Rhamnus Disperma.", PHYTOCHEMISTRY, vol. 52, no. 5, 31 December 1999 (1999-12-31), pages 943 - 946, XP004291095, DOI: doi:10.1016/S0031-9422(99)00262-9
CHO, J.G. ET AL.: "Flavonoids from the Grains of C1/R-S Transgenic Rice, the Transgenic Oryza Sativa Spp. Japonica, and Their Radical Scavenging Activities.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 61, no. 43, 27 September 2013 (2013-09-27), pages 10354 - 10359
GROUILLER, A. ET AL.: "Chemistry of Flavone Compounds. III. Synthesis of Mono-And Bis (O-Glucosyl) Flavonols.", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE ., 31 December 1966 (1966-12-31), pages 987 - 91
KAJJOUT, M. ET AL.: "Regiospecific Synthesis of Quercetin O-beta -D-Glucosylated and O- beta -D-Glucuronidated Isomers.", TETRAHEDRON, vol. 67, no. 25, 8 August 2011 (2011-08-08), pages 4731 - 4741
WANG, YIHAI ET AL.: "Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus Alba L.) Polyphenol Enhanced Extract.", PLOS ONE., vol. 8, no. 7, 30 July 2013 (2013-07-30), pages e71144
SEPULVEDA-BOZA, S. ET AL.: "Flavonoids from the Twigs of Eucryphia Glutinosa.", PHYTOCHEMISTRY, vol. 32, no. 5, 31 December 1993 (1993-12-31), pages 1301 - 3
MARZOUK, M.S. ET AL.: "Polyphenolic Metabolites of Rhamnus Disperma.", PHYTOCHEMISTRY, vol. 52, no. 5, 31 December 1999 (1999-12-31), pages 943 - 946, XP004291095, DOI: doi:10.1016/S0031-9422(99)00262-9
CHO, J.G. ET AL.: "Flavonoids from the Grains of C1/R-S Transgenic Rice, the Transgenic Oryza Sativa Spp. Japonica, and Their Radical Scavenging Activities.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 61, no. 43, 27 September 2013 (2013-09-27), pages 10354 - 10359
GROUILLER, A. ET AL.: "Chemistry of Flavone Compounds. III. Synthesis of Mono-And Bis (O-Glucosyl) Flavonols.", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE ., 31 December 1966 (1966-12-31), pages 987 - 91
KAJJOUT, M. ET AL.: "Regiospecific Synthesis of Quercetin O-beta -D-Glucosylated and O- beta -D-Glucuronidated Isomers.", TETRAHEDRON, vol. 67, no. 25, 8 August 2011 (2011-08-08), pages 4731 - 4741
Attorney, Agent or Firm:
HANGZHOU XINYUAN PATENT AGENCY (CN)
杭州新源专利事务所 (CN)
杭州新源专利事务所 (CN)
Download PDF: