FLAVONOID GLYCOSIDE-ORGANOAMINE DPP-4 INHIBITOR DOUBLE SALT, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF - HANGZHOU LALIN INTELLIGENCE SCIENCE AND TECH CO LTD

Title:

FLAVONOID GLYCOSIDE-ORGANOAMINE DPP-4 INHIBITOR DOUBLE SALT, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/089589

Kind Code:

A1

Abstract:

A flavonoid glycoside-organoamine DPP-4 inhibitor double salt. The flavonoid glycoside has the structural formula as shown in formula (1), wherein R1-R9 are independently selected from a group consisting of -H, -OH, C1-C6 alkyl, alkoxy or substituted alkyl, and at least one of R1 and R2 is selected from -OH. Also involved are a preparation method for the double salt, a pharmaceutical composition containing a therapeutic amount of active ingredients, and an application thereof. Further involved are double salt nanoparticles obtained by nano-grinding of the double salt compound and an application thereof.

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Inventors:

WANG HUALU (CN)
WANG LUYING (CN)

Application Number:

PCT/CN2021/127466

Publication Date:

May 05, 2022

Filing Date:

October 29, 2021

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Assignee:

HANGZHOU LALIN INTELLIGENCE SCIENCE AND TECH CO LTD (CN)

International Classes:

C07H17/07; A61K31/403; A61K31/4985; A61K31/513; A61K31/7048; A61P3/10; C07D209/52; C07D239/553; C07D487/04; C07H1/00

Domestic Patent References:

WO2013046229A1

2013-04-04

Foreign References:

CN103649090A	2014-03-19
CN102086172A	2011-06-08
CN110314233A	2019-10-11
CN101732417A	2010-06-16
CN113880900A	2022-01-04

Other References:

SOKAR SAMIA SALEM; EL-SAYAD MAGDA EL-SAYED; GHONEIM MAI EL-SAYED; SHEBL ABDELHADI MOHAMED: "Combination of Sitagliptin and Silymarin ameliorates liver fibrosis induced by carbon tetrachloride in rats", BIOMEDICINE & PHARMACOTHERAPY, vol. 89, 20 February 2017 (2017-02-20), FR , pages 98 - 107, XP029987163, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2017.02.010

Attorney, Agent or Firm:

ACIP LAW OFFICES (CN)

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