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Title:
FLUORESCENT PROBE FOR DETECTING ALKALINE PHOSPHATASE, AND USE FOR SAME
Document Type and Number:
WIPO Patent Application WO/2018/159810
Kind Code:
A1
Abstract:
Provided is a fluorescent probe for detecting alkaline phosphatase. The fluorescent probe is suitable for measurements that require high sensitivity and quantitativity. A fluorescent probe for detecting alkaline phosphatase, the fluorescent probe including a compound that has an anionic functional group and a phosphate group.

Inventors:
URANO YASUTERU (JP)
KOMATSU TORU (JP)
SAKAMOTO SHINGO (JP)
NOJI HIROYUKI (JP)
WATANABE RIKIYA (JP)
ZHANG YI (JP)
Application Number:
PCT/JP2018/007993
Publication Date:
September 07, 2018
Filing Date:
March 02, 2018
Export Citation:
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Assignee:
UNIV TOKYO (JP)
International Classes:
G01N33/58; C09B11/26; C09B11/28; C09B57/02; C12Q1/42; G01N33/483
Domestic Patent References:
WO2012099218A12012-07-26
WO2005024049A12005-03-17
Foreign References:
JPS59130284A1984-07-26
JP2007533828A2007-11-22
US20100086957A12010-04-08
Other References:
FUJITA, SATOSHI ET AL.: "Highly sensitive detection of membrane-bound DNA using fluorescein derivatives", ANALYTICA CHIMICA ACTA, vol. 339, 1997, pages 289 - 296, XP055538430
WAHLER, DENIS ET AL.: "Enzyme Fingerprints of Activity, and Stereo- and Enantioselectivity from Fluorogenic and Chromogenic Substrate Arrays", CHEMISTRY A EUROPEAN JOURNAL, vol. 8, no. 14, 2002, pages 3211 - 3228, XP002255071
OBAYASHI, YUSUKE ET AL.: "A single-molecule digital enzyme assay using alkaline phosphatase with a cumarin-based fluorogenic substrate", ANALYST, vol. 140, 2015, pages 5065 - 5073, XP055529811
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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