Title:
FLUORESCENT PROBE FOR DETECTING ALKALINE PHOSPHATASE, AND USE FOR SAME
Document Type and Number:
WIPO Patent Application WO/2018/159810
Kind Code:
A1
Abstract:
Provided is a fluorescent probe for detecting alkaline phosphatase. The fluorescent probe is suitable for measurements that require high sensitivity and quantitativity. A fluorescent probe for detecting alkaline phosphatase, the fluorescent probe including a compound that has an anionic functional group and a phosphate group.
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Inventors:
URANO YASUTERU (JP)
KOMATSU TORU (JP)
SAKAMOTO SHINGO (JP)
NOJI HIROYUKI (JP)
WATANABE RIKIYA (JP)
ZHANG YI (JP)
KOMATSU TORU (JP)
SAKAMOTO SHINGO (JP)
NOJI HIROYUKI (JP)
WATANABE RIKIYA (JP)
ZHANG YI (JP)
Application Number:
PCT/JP2018/007993
Publication Date:
September 07, 2018
Filing Date:
March 02, 2018
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
G01N33/58; C09B11/26; C09B11/28; C09B57/02; C12Q1/42; G01N33/483
Domestic Patent References:
WO2012099218A1 | 2012-07-26 | |||
WO2005024049A1 | 2005-03-17 |
Foreign References:
JPS59130284A | 1984-07-26 | |||
JP2007533828A | 2007-11-22 | |||
US20100086957A1 | 2010-04-08 |
Other References:
FUJITA, SATOSHI ET AL.: "Highly sensitive detection of membrane-bound DNA using fluorescein derivatives", ANALYTICA CHIMICA ACTA, vol. 339, 1997, pages 289 - 296, XP055538430
WAHLER, DENIS ET AL.: "Enzyme Fingerprints of Activity, and Stereo- and Enantioselectivity from Fluorogenic and Chromogenic Substrate Arrays", CHEMISTRY A EUROPEAN JOURNAL, vol. 8, no. 14, 2002, pages 3211 - 3228, XP002255071
OBAYASHI, YUSUKE ET AL.: "A single-molecule digital enzyme assay using alkaline phosphatase with a cumarin-based fluorogenic substrate", ANALYST, vol. 140, 2015, pages 5065 - 5073, XP055529811
WAHLER, DENIS ET AL.: "Enzyme Fingerprints of Activity, and Stereo- and Enantioselectivity from Fluorogenic and Chromogenic Substrate Arrays", CHEMISTRY A EUROPEAN JOURNAL, vol. 8, no. 14, 2002, pages 3211 - 3228, XP002255071
OBAYASHI, YUSUKE ET AL.: "A single-molecule digital enzyme assay using alkaline phosphatase with a cumarin-based fluorogenic substrate", ANALYST, vol. 140, 2015, pages 5065 - 5073, XP055529811
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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