Title:
FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2019/168199
Kind Code:
A1
Abstract:
[Problem] To provide a fluorescent probe which includes, as the base nucleus, a fluorescent skeleton functioning in the visible light region and which makes carboxypeptidase activity visible with high sensitivity.
[Solution] A compound represented by general formula (I) or a salt of the compound.
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Inventors:
URANO YASUTERU (JP)
KAMIYA MAKO (JP)
KAWATANI MINORU (JP)
IWAKI HIROHISA (JP)
YAMAMOTO KYOKO (JP)
KUME HARUKI (JP)
YAMADA DAISUKE (JP)
KAMIYA MAKO (JP)
KAWATANI MINORU (JP)
IWAKI HIROHISA (JP)
YAMAMOTO KYOKO (JP)
KUME HARUKI (JP)
YAMADA DAISUKE (JP)
Application Number:
PCT/JP2019/008403
Publication Date:
September 06, 2019
Filing Date:
March 04, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C09B29/01; C12Q1/37; G01N33/573; C07D311/90; C07D493/10
Foreign References:
| US20060003383A1 | 2006-01-05 |
Other References:
MOCK, WILLIAM L. ET AL.: "Arazoformyl peptide surrogates as spectrophotometric kinetic asay substrates for carboxypeptidase A", ANALYTICAL BIOCHEMISTRY, vol. 239, no. 2, 1996, pages 218 - 222, XP002196534, ISSN: 0960-894X, doi:10.1006/abio.1996.0318
MOCK, WILLIAM L. ET AL.: "Catalytic activity of carboxypeptidase B and of carboxypeptidase Y with anisylazoformyl substrates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 2, 1999, pages 187 - 192, XP004152597, ISSN: 0960-894X, doi:10.1016/S0960-894X(98)00715-X
KURIKI, YUGO ET AL.: "Establishment of molecular desigh strategy to obtain activatable fluorescent probes for carboxypeptidases", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 5, 2018, pages 1767 - 1773, XP055633935, ISSN: 1520-5126
1 February 2018 (2018-02-01), Retrieved from the Internet
MOCK, WILLIAM L. ET AL.: "Catalytic activity of carboxypeptidase B and of carboxypeptidase Y with anisylazoformyl substrates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 2, 1999, pages 187 - 192, XP004152597, ISSN: 0960-894X, doi:10.1016/S0960-894X(98)00715-X
KURIKI, YUGO ET AL.: "Establishment of molecular desigh strategy to obtain activatable fluorescent probes for carboxypeptidases", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 5, 2018, pages 1767 - 1773, XP055633935, ISSN: 1520-5126
1 February 2018 (2018-02-01), Retrieved from the Internet
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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