Title:
FLUORESCENT PROBE FOR DETECTION OF ENPP ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2020/246616
Kind Code:
A1
Abstract:
[Problem] To provide a novel fluorescent probe. [Solution] The compound represented by general formula (I), or a salt thereof.
Inventors:
URANO YASUTERU (JP)
KOMATSU TORU (JP)
SAKAMOTO SHINGO (JP)
NOJI HIROYUKI (JP)
NAKAGAWA HIDEHIKO (JP)
KAWAGUCHI MITSUYASU (JP)
WATANABE RIKIYA (JP)
KOMATSU TORU (JP)
SAKAMOTO SHINGO (JP)
NOJI HIROYUKI (JP)
NAKAGAWA HIDEHIKO (JP)
KAWAGUCHI MITSUYASU (JP)
WATANABE RIKIYA (JP)
Application Number:
PCT/JP2020/022546
Publication Date:
December 10, 2020
Filing Date:
June 08, 2020
Export Citation:
Assignee:
UNIV TOKYO (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
RIKEN (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
RIKEN (JP)
International Classes:
C07H19/10; C07H19/20
Domestic Patent References:
| WO2010126075A1 | 2010-11-04 | |||
| WO2018159810A1 | 2018-09-07 | |||
| WO2018159810A1 | 2018-09-07 |
Foreign References:
| JP2016512042A | 2016-04-25 |
Other References:
MITSUYASU KAWAGUCHI, XIANG HAN, NAOYA LEDA, KUNIYUKI KANO, JUNKEN AOKI, HIDEHIKO NAKAGAWA: "1P-036 Development of ENPP1 fluorescence probe and chemical screening", 35TH MEDICAL CHEMISTRY SYMPOSIUM, OCTOBER 25-27, 2017, NAGOYA, vol. 35, 30 November 2016 (2016-11-30) - 27 October 2017 (2017-10-27), JAPAN , pages 98, XP009533494, ISSN: 0919-214X
KAWAGUCHI MITSUYASU, OKABE TAKAYOSHI, OKUDAIRA SHINICHI, NISHIMASU HIROSHI, ISHITANI RYUICHIRO, KOJIMA HIROTATSU, NUREKI OSAMU, AO: "Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors , Using a Newly Developed Fluorescence Probe", ACS CHEMICAL BIOLOGY, vol. 8, no. 8, 2013, pages 1713 - 1721, XP055768645
KAWAGUCHI, M. ET AL.: "Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 31, 2011, pages 12021 - 12030, XP055372580, DOI: 10.1021/ja201028t
M. KAWAGUCHIT. OKABES. OKUDAIRAH. NISHIMASUR. ISHITANIH. KOJIMA0. NUREKIJ. AOKIT. NAGANO: "Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe", ACS CHEM. BIOL., vol. 8, 2013, pages 1713 - 1721, XP055768645, DOI: 10.1021/cb400150c
KAWAGUCHI MITSUYASU, OKABE TAKAYOSHI, OKUDAIRA SHINICHI, NISHIMASU HIROSHI, ISHITANI RYUICHIRO, KOJIMA HIROTATSU, NUREKI OSAMU, AO: "Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors , Using a Newly Developed Fluorescence Probe", ACS CHEMICAL BIOLOGY, vol. 8, no. 8, 2013, pages 1713 - 1721, XP055768645
KAWAGUCHI, M. ET AL.: "Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 31, 2011, pages 12021 - 12030, XP055372580, DOI: 10.1021/ja201028t
M. KAWAGUCHIT. OKABES. OKUDAIRAH. NISHIMASUR. ISHITANIH. KOJIMA0. NUREKIJ. AOKIT. NAGANO: "Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe", ACS CHEM. BIOL., vol. 8, 2013, pages 1713 - 1721, XP055768645, DOI: 10.1021/cb400150c
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
Download PDF:
Previous Patent: ASSESSMENT SYSTEM
Next Patent: INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD, PROGRAM, AND METHOD FOR PRODUCING ANTI...
Next Patent: INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING METHOD, PROGRAM, AND METHOD FOR PRODUCING ANTI...