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Title:
FLUORESCENT PROBE FOR DETECTION OF ENPP ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2020/246616
Kind Code:
A1
Abstract:
[Problem] To provide a novel fluorescent probe. [Solution] The compound represented by general formula (I), or a salt thereof.

Inventors:
URANO YASUTERU (JP)
KOMATSU TORU (JP)
SAKAMOTO SHINGO (JP)
NOJI HIROYUKI (JP)
NAKAGAWA HIDEHIKO (JP)
KAWAGUCHI MITSUYASU (JP)
WATANABE RIKIYA (JP)
Application Number:
PCT/JP2020/022546
Publication Date:
December 10, 2020
Filing Date:
June 08, 2020
Export Citation:
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Assignee:
UNIV TOKYO (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
RIKEN (JP)
International Classes:
C07H19/10; C07H19/20
Domestic Patent References:
WO2010126075A12010-11-04
WO2018159810A12018-09-07
WO2018159810A12018-09-07
Foreign References:
JP2016512042A2016-04-25
Other References:
MITSUYASU KAWAGUCHI, XIANG HAN, NAOYA LEDA, KUNIYUKI KANO, JUNKEN AOKI, HIDEHIKO NAKAGAWA: "1P-036 Development of ENPP1 fluorescence probe and chemical screening", 35TH MEDICAL CHEMISTRY SYMPOSIUM, OCTOBER 25-27, 2017, NAGOYA, vol. 35, 30 November 2016 (2016-11-30) - 27 October 2017 (2017-10-27), JAPAN , pages 98, XP009533494, ISSN: 0919-214X
KAWAGUCHI MITSUYASU, OKABE TAKAYOSHI, OKUDAIRA SHINICHI, NISHIMASU HIROSHI, ISHITANI RYUICHIRO, KOJIMA HIROTATSU, NUREKI OSAMU, AO: "Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors , Using a Newly Developed Fluorescence Probe", ACS CHEMICAL BIOLOGY, vol. 8, no. 8, 2013, pages 1713 - 1721, XP055768645
KAWAGUCHI, M. ET AL.: "Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, no. 31, 2011, pages 12021 - 12030, XP055372580, DOI: 10.1021/ja201028t
M. KAWAGUCHIT. OKABES. OKUDAIRAH. NISHIMASUR. ISHITANIH. KOJIMA0. NUREKIJ. AOKIT. NAGANO: "Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe", ACS CHEM. BIOL., vol. 8, 2013, pages 1713 - 1721, XP055768645, DOI: 10.1021/cb400150c
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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