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Title:
FLUORESCENT TRACEABLE AMINO ACID DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/028421
Kind Code:
A1
Abstract:
Provided by the present invention are a fluorescent traceable amino acid derivative, a preparation method therefor, and an application thereof, belonging to the technical field of biomedicine. The amino acid derivative provided by the present invention primarily uses a fluorescent traceable functional group to perform modification on an amino acid backbone, and NBD-Cl (4-chloro-7-nitro-2,1,3-benzoxadiazole) has properties of low polarity and strong fluorescence, using same to modify an N-terminus of the amino acid backbone, same can be used for subcellular imaging, is relatively low in volume, lacks reaction orthogonality, and has little interference with an innate biochemical reaction of an organism. A result of an embodiment shows that the fluorescent traceable amino acid derivative provided by the present invention has good biological activity, and fluorescent tracing can be performed in vivo or in vitro.

Inventors:
WANG YUJI (CN)
WANG YANMING (CN)
ZHU DI (CN)
LU YU (CN)
LIU BOTAO (CN)
QU AIJUAN (CN)
Application Number:
PCT/CN2021/110331
Publication Date:
February 10, 2022
Filing Date:
August 03, 2021
Export Citation:
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Assignee:
CAPITAL MEDICAL UNIV (CN)
International Classes:
A61K31/04; C07D271/12; A61K31/16; A61K31/165; A61K31/41; A61K31/4245; A61K49/00; A61P35/00; C07D413/12; C09K11/06; G01N21/64
Foreign References:
CN111848544A2020-10-30
CN104478823A2015-04-01
JPS61129175A1986-06-17
CN110366552A2019-10-22
Other References:
SATO E. ET AL.: "A Potentially Useful Fluorogenic Amine, 4-Amino-7-nitrobenz-2-oxa-1, 3-diazole. An Application as a Substrate for a Microdetermination of Chymotrypsin", CHEM. PHARM. BULL, vol. 32, no. 1, 25 January 1984 (1984-01-25), pages 336 - 339, XP055894414, ISSN: 0009-2363
ZHAO, HUA: "Determination of the Four Threonine Isomers and Isoleucine in Mammals", DOCTORAL DISSERTATION, 1 May 2006 (2006-05-01), China, pages 1 - 93, XP009534032
MENG RUAN, QIQIN WANG, HUIHUI WU, YUQIANG WANG, HAI HAN, ZHENGJIN JIANG: "Preparation and evaluation of tert -leucine derivative functionalized polymeric monoliths for micro-liquid chromatography", ELECTROPHORESIS, vol. 38, no. 22-23, 1 November 2017 (2017-11-01), pages 3020 - 3028, XP055727663, ISSN: 0173-0835, DOI: 10.1002/elps.201700176
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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