FUCOSYLATED CHONDROITIN SULFATE OLIGOSACCHARIDE, PREPARATION METHOD THEREFOR, COMPOSITION THEREOF AND USE THEREOF

Title:

FUCOSYLATED CHONDROITIN SULFATE OLIGOSACCHARIDE, PREPARATION METHOD THEREFOR, COMPOSITION THEREOF AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2020/015612

Kind Code:

A1

Abstract:

A fucosylated chondroitin sulfate oligosaccharide having the structure as shown in J, and further disclosed is a method for preparing the fucosylated chondroitin sulfate oligosaccharide: using a chondroitin sulfate A salt as a raw material, sequentially performing enzymolysis, a group protection operation, and glycosylation to synthesize the oligosacchaide compound; the certainty of the described structure allows said oligosaccharide to be applied to the medical field.

Inventors:

LI ZHONGJUN (CN)
ZHANG XIAO (CN)
LIU HUIYING (CN)
YAO WANG (CN)

Application Number:

PCT/CN2019/096033

Publication Date:

January 23, 2020

Filing Date:

July 15, 2019

Export Citation:

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Assignee:

UNIV BEIJING (CN)

International Classes:

C07H11/00; A61P29/00; C07H13/08

Foreign References:

CN106349407A	2017-01-25
CN107261147A	2017-10-20
JP6147322B2	2017-06-14
CN109912668A	2019-06-21
CN108794653A	2018-11-13

Other References:

J. BIOL. CHEM., vol. 263, 1988, pages 18176
MAR. DRUGS, vol. 12, 2014, pages 232
P NATL ACAD SCI USA, vol. 112, 2015, pages 8284
J. BIOL. CHEM, vol. 289, 2014, pages 28284
CARBOHYDR. POLYM, vol. 127, 2015, pages 427
TETRAHEDRON. LETT, vol. 54, 2013, pages 3940
BIOMACROMOLECULES, vol. 16, 2015, pages 2237
CHEM. EUR. J, vol. 22, 2016, pages 18215
J. BIOL, CHEM, vol. 289, 2014, pages 28284
CARBOHYDR. POLYM, vol. 83, 2011, pages 688
See also references of EP 3819302A4

Attorney, Agent or Firm:

AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)

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