Title:
FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS
Document Type and Number:
WIPO Patent Application WO2000042045
Kind Code:
A3
Abstract:
The present invention is a novel series of functionalized heterocycles as chemokine receptor modulators of Formula (I) useful as modulators of chemokine receptor activity. The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the prepartion of the final products, pharmaceutical compositions containing the final products are also taught.
Inventors:
HARRIMAN GERALDINE C (US)
KOLZ CHRISTINE NYLUND (US)
LULY JAY R (US)
ROTH BRUCE DAVID (US)
SONG YUNTAO (US)
TRIVEDI BHARAT KALIDAS (US)
KOLZ CHRISTINE NYLUND (US)
LULY JAY R (US)
ROTH BRUCE DAVID (US)
SONG YUNTAO (US)
TRIVEDI BHARAT KALIDAS (US)
Application Number:
PCT/US1999/030434
Publication Date:
November 09, 2000
Filing Date:
December 20, 1999
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
HARRIMAN GERALDINE C (US)
KOLZ CHRISTINE NYLUND (US)
LULY JAY R (US)
ROTH BRUCE DAVID (US)
SONG YUNTAO (US)
TRIVEDI BHARAT KALIDAS (US)
HARRIMAN GERALDINE C (US)
KOLZ CHRISTINE NYLUND (US)
LULY JAY R (US)
ROTH BRUCE DAVID (US)
SONG YUNTAO (US)
TRIVEDI BHARAT KALIDAS (US)
International Classes:
A61K31/437; A61K31/4375; A61P31/18; C07D455/02; C07D491/14; C07D491/22; C07D491/147; (IPC1-7): C07D491/22; A61P31/18; A61K31/438; A61K31/436; C07D491/14; C07D455/02
Domestic Patent References:
| WO1998038167A1 | 1998-09-03 | |||
| WO1999038514A1 | 1999-08-05 |
Foreign References:
| US3565903A | 1971-02-23 | |||
| US3518258A | 1970-06-30 | |||
| US3549641A | 1970-12-22 | |||
| US5635510A | 1997-06-03 | |||
| EP0820998A2 | 1998-01-28 |
Other References:
M. VON STRANDTMANN ET AL.: "Reaction of Phenolic Mannich Bases with Enamines. General Synthesis of Pyran-Containing Fused Ring Systems.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 7, 1970, HETEROCORPORATION. PROVO., US, pages 1311 - 1319, XP002143638, ISSN: 0022-152X
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