Title:
FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/052499
Kind Code:
A1
Abstract:
Disclosed in the present invention are a fused pyridone compound, and a preparation method therefor and a use thereof. Specifically, the present invention discloses a compound of formula (I-B), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a KRAS inhibitor.
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Inventors:
GUO SHUCHUN (CN)
FAN JUN (CN)
LIU YANG (CN)
BAO FANG (CN)
PENG JIANBIAO (CN)
GUO HAIBING (CN)
FAN JUN (CN)
LIU YANG (CN)
BAO FANG (CN)
PENG JIANBIAO (CN)
GUO HAIBING (CN)
Application Number:
PCT/CN2020/116510
Publication Date:
March 25, 2021
Filing Date:
September 21, 2020
Export Citation:
Assignee:
SHANGHAI JEMINCARE PHARMACEUTICALS CO LTD (CN)
JIANGXI JEMINCARE GROUP CO LTD (CN)
JIANGXI JEMINCARE GROUP CO LTD (CN)
International Classes:
A61P35/00; C07D471/14; C07D471/22; C07D498/14
Domestic Patent References:
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| WO2018142365A1 | 2018-08-09 | |||
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Other References:
MCGRAW-HILL: "Dictionary of Chemical Ter is", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
ARLINGER N.L.ELIEL E.L.: "Topics in Stereochemistry", vol. 6, 1971, WILEY INTERSCIENCE
BETHANY HALFORD: "Amgen unveils its KRas covalent inhibitor AMG 510", CHEMICAL & ENGINEERING NEWS, vol. 97, no. 14, 8 April 2019 (2019-04-08), pages 4 - 4, XP055694388, DOI: 10.1021/cen-09714-scicon1
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
ARLINGER N.L.ELIEL E.L.: "Topics in Stereochemistry", vol. 6, 1971, WILEY INTERSCIENCE
BETHANY HALFORD: "Amgen unveils its KRas covalent inhibitor AMG 510", CHEMICAL & ENGINEERING NEWS, vol. 97, no. 14, 8 April 2019 (2019-04-08), pages 4 - 4, XP055694388, DOI: 10.1021/cen-09714-scicon1
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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