Title:
GAMBOGIC GLYCOSIDE DERIVATIVES AND ANALOGS, THE PREPARATION AND THE APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/043296
Kind Code:
A1
Abstract:
The invention discloses gambogic glycoside derivatives and analogs represented by formula I, the preparation and the application thereof, wherein the substituents R1-R12 are defined as in the description. The gambogic glycoside derivatives and analogs of the invention were synthesized from extracted and purified gambogic acid. The obtained gambogic glycoside derivatives and analogs have antitumor, antivirus, antibacterial and antifungal activities and can be used as antitumor, antivirus, immune, antibacterial and antifungal medicines. The gambogic glycoside derivatives and analogs of the invention can be used together with other known antitumor, antivirus, immune, antibacterial and antifungal medicines.
Inventors:
XU LIFENG (CN)
Application Number:
PCT/CN2008/072540
Publication Date:
April 09, 2009
Filing Date:
September 26, 2008
Export Citation:
Assignee:
LIAONING LIFENG SCIENT & TECHN (CN)
XU LIFENG (CN)
XU LIFENG (CN)
International Classes:
C07H17/04; A61K31/7048; A61P35/00
Domestic Patent References:
| WO2000044216A2 | 2000-08-03 | |||
| WO2000044216A2 | 2000-08-03 |
Foreign References:
| CN1563014A | 2005-01-12 | |||
| CN1738620A | 2006-02-22 | |||
| CN1715283A | 2006-01-04 | |||
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Other References:
FENG, FENG ET AL.: "Study on derivatives of gambogic acid.", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY., vol. 36, no. 4, 2005, pages 302 - 305, XP008134472
JUN A ET AL.: "Cytotoxic xanthones from gamboge", J. PHYTOCHEM ISTRY, 1996
XIANG S.R; CHEN TK; HUANG, Y.C. ET AL.: "Effect on tumor S180 and ascites by gambogic acid", J. ACTA ACAD MED JIANG XI, 1981, pages 172211
JUN A ET AL.: "Cytotoxic xanthones from gamboge", J. PHYTOCHEM ISTRY, 1996
XIANG S.R; CHEN TK; HUANG, Y.C. ET AL.: "Effect on tumor S180 and ascites by gambogic acid", J. ACTA ACAD MED JIANG XI, 1981, pages 172211
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (Heping DistrictShenyang, Liaoning 4, CN)
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