Title:
A GENETICALLY MODIFIED MOUSE EXPRESSING HUMAN APOE4 AND MOUSE Trem2 p.R47H AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/175581
Kind Code:
A8
Abstract:
Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non- familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.
Inventors:
HOWELL GARETH (US)
SASNER MICHAEL (US)
CARTER GREGORY (US)
LAMB BRUCE (US)
SASNER MICHAEL (US)
CARTER GREGORY (US)
LAMB BRUCE (US)
Application Number:
PCT/US2018/023565
Publication Date:
December 27, 2018
Filing Date:
March 21, 2018
Export Citation:
Assignee:
JACKSON LAB (US)
UNIV INDIANA RES & TECH CORP (US)
UNIV INDIANA RES & TECH CORP (US)
International Classes:
A01K67/027; C07K14/705; C07K14/775; G01N33/48
Attorney, Agent or Firm:
DIPIETRANTONIO, Heather, J. et al. (US)
Download PDF: