Title:
GINKGOLIDE B DERIVATIVE AND SALT THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/215895
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicine, and relates to derivatives represented by formula 1 and formula 2 in which a carboxylic acid group is introduced into the structure of ginkgolide B by means of a hydroxyl group at the 10-position and ester derivatives of carboxylic acid groups, as well as pharmaceutically acceptable organic or inorganic salts. The present invention uses ginkgolide B as a parent body; ginkgolide B is prepared by means of chemical structure modification so as to achieve the goals of improving solubility, increasing bioavailability and enhancing a healing efficacy. The prepared compound and carboxylate salts thereof have significant platelet activating factor antagonism, an anticoagulant effect and an anti-acute cerebral ischemia effect, and can be used for preparing a drug for preventing and treating ischemic stroke, thrombosis, angina pectoris, cardiopulmonary infarction, as well as inflammation, asthma and other diseases related to a platelet activating factor. (1), (2)
Inventors:
ZHANG QIAN (CN)
TANG JIAN (CN)
TANG JIAN (CN)
Application Number:
PCT/CN2020/077521
Publication Date:
October 29, 2020
Filing Date:
March 03, 2020
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
C07D493/22; A61K31/365; A61P7/02; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P29/00; C07C209/00; C07C211/05; C07C211/07; C07C213/08; C07C215/10; C07C227/18; C07C229/26; C07C257/14; C07D233/64; C07D295/023; C07D295/037
Domestic Patent References:
| WO2006083366A2 | 2006-08-10 |
Foreign References:
| CN110054634A | 2019-07-26 | |||
| CN109485674A | 2019-03-19 | |||
| CN1837212A | 2006-09-27 | |||
| CN104098584A | 2014-10-15 | |||
| CN1139435A | 1997-01-01 | |||
| CN201910338234A | 2019-04-24 |
Other References:
DATABASE REGISTRY 22 November 2006 (2006-11-22), retrieved from STN Database accession no. 913942-98-0
See also references of EP 3964514A4
See also references of EP 3964514A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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